Asymmetric Synthesis of Chiral Sulfoxides
Asymmetric Synthesis of Chiral Sulfoxides
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手性亚砜的不对称合成
DOI：
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发表时间：
2009
期刊：
影响因子：
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通讯作者：
H. Kagan
中科院分区：
文献类型：
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作者：
H. Kagan
对映纯亚砜是不对称合成中重要的助剂，有些还具有有用的生物学性质。在本章中，描述了基于不对称合成的手性亚砜的各种途径。详细介绍了亚砜如亚磺酸盐或亚砜酰胺的手性前体的制备和使用。然后讨论了硫化物的对映选择性催化氧化，特别注意了所使用的各种金属配合物。最后，描述了手性恶氮嘧啶或其他手性有机氧化剂对硫化物的化学计量氧化。1.1手性亚砜
Enantiopure sulfoxides are important auxiliaries in asymmetric synthesis, and some also have useful biological properties. In this chapter, the various routes to chiral sulfoxides are described, when these are based on asymmetric synthesis. Details are provided of the preparation and use of chiral precursors of sulfoxides such as sulfinates or sulfinamides. The enantioselective catalytic oxidation of sulfides is then discussed, with particular attention being paid to the various metal complexes which have been used. Finally, the stoichiometric oxidation of sulfides by chiral oxaziridines or other chiral organic oxidants is described. 1.1 Chiral Sulfoxides