Optimal number of pulses as outcome measures of neuronavigated transcranial magnetic stimulation.
Optimal number of pulses as outcome measures of neuronavigated transcranial magnetic stimulation.
复制标题
最佳数量的脉冲数量作为神经腔内颅磁刺激的结果度量。
DOI：
10.1016/j.clinph.2016.04.001
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发表时间：
2016-08
期刊：
影响因子：
--
通讯作者：
Pascual-Leone A
中科院分区：
文献类型：
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作者：
Chang WH;Fried PJ;Saxena S;Jannati A;Gomes-Osman J;Kim YH;Pascual-Leone A
确定在经颅磁刺激（TMS）研究中实现可靠的运动诱发电位（MEPs）测量所需的最佳脉冲数。回顾性数据来自54名健康志愿者（30名男性，平均年龄61.7±13.1岁），作为先前研究的一部分，他们使用神经导航完成了3个连续30次的经颅磁刺激。评估了四种方案的数据：单脉冲TMS用于测量mep的幅度和潜伏期；配对脉冲TMS用于短间隔皮质内抑制（sICI）和皮质内促进（ICF）；和单脉冲经颅磁刺激来评估间歇性θ波爆发刺激（iTBS）的效果。采用了两种统计方法：内部一致性分析和mep平均振幅周围95%置信区间（CI）的纳入概率。对于单脉冲TMS，获得可靠的幅度和潜伏期mep测量所需的最小脉冲数分别为21和23。对于配对脉冲TMS，实现可靠的sICI和ICF测量所需的最小脉冲数分别为20和25。最后，在iTBS后获得可靠的幅度和延迟mep测量所需的最小脉冲数分别为22和23。本研究提供了关于在使用神经导航TMS的各种研究方案中实现可靠的MEPs测量所需的最小脉冲数的指导方针。这项研究的结果有可能提高未来神经导航经颅磁刺激研究的可靠性和质量。
Identify the optimal number of pulses necessary to achieve reliable measures of motor evoked potentials (MEPs) in transcranial magnetic stimulation (TMS) studies. Retrospective data was obtained from 54 healthy volunteers (30 men, mean age 61.7±13.1 years) who as part of prior studies had completed three blocks of 30 consecutive TMS stimuli using neuronavigation. Data from four protocols were assessed: single-pulse TMS for measures of amplitude and latency of MEPs; paired-pulse TMS for short-interval intracortical inhibition (sICI) and intracortical facilitation (ICF); and single-pulse TMS to assess the effects of intermittent theta burst stimulation (iTBS). Two statistical methods were used: an internal consistency analysis and probability of inclusion in the 95% confidence interval (CI) around the mean MEPs amplitude. For single-pulse TMS, the minimum number of pulses needed to achieve reliable amplitude and latency MEPs measures was 21 and 23, respectively. For paired-pulse TMS, the minimum number of pulses needed to achieve reliable sICI and ICF measures was 20 and 25, respectively. Finally, the minimum number of pulses needed to achieve reliable amplitude and latency MEPs measures after iTBS was 22 and 23, respectively. This study provides guidelines regarding the minimum number of pulses needed to achieve reliable MEPs measurements in various study protocols using neuronavigated TMS. Results from this study have the potential to increase the reliability and quality of future neuronavigated TMS studies.