Interactions between age and apoE genotype on fasting and postprandial triglycerides levels
Interactions between age and apoE genotype on fasting and postprandial triglycerides levels
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DOI：
10.1016/j.atherosclerosis.2010.06.036
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发表时间：
2010-10-01
期刊：
影响因子：
5.3
通讯作者：
Minihane, Anne M.
中科院分区：
文献类型：
--
作者：
Carvalho-Wells, Andrew L.;Jackson, Kim G.;Minihane, Anne M.
目的：遗传因素对餐后血脂水平的影响目前尚不清楚。在此，确定常见载脂蛋白（apo）E β突变对餐后甘油三酯（TG）反应的影响，沿着根据年龄、体重指数和性别评估基因型突变率。方法和结果：健康成人（n=251）进行了餐后调查，其中血液样本采取定期测试早餐后（0分钟，49 g脂肪）和午餐（330分钟，29 g脂肪），直到测试早餐后480分钟。apoE基因型对空腹总胆固醇（TC）（P=0.027）、低密度脂蛋白胆固醇（LDL-C）（P=0.008）和%LDL 3（P=0.001）有显著影响，相对于E3/E3基因型，E4和E2携带者的水平分别较高和较低。E4携带者的餐后TG反应曲线下面积（TG AUC）明显高于E3/E3组（P=0.038），反映了空腹TG较高（P = 0.001）。在整个组中，观察到空腹TC的显著年龄x基因型相互作用（P=0.021）。在>50岁的参与者中，基因型对TC（P=0.005）、LDL-C（P=0.001）和TAG AUC（P=0.028）有显著影响。结论：可能是夸大的餐后脂血症导致与E4等位基因携带者相关的冠心病风险增加;这种效应在老年人中更为明显。(C)2010爱思唯尔爱尔兰有限公司版权所有。
Objective: The influences of genetic determinants on the magnitude of postprandial lipaemia are presently unclear. Here the impact of the common apolipoprotein (apo)E epsilon mutation on the postprandial triglyceride (TG) response is determined, along with an assessment of genotype penetrance according to age, body mass index and gender.Methods and results: Healthy adults (n=251) underwent a postprandial investigation, in which blood samples were taken at regular intervals after a test breakfast (0 min, 49 g fat) and lunch (330 min, 29 g fat) until 480 min after the test breakfast. There was a significant impact of apoE genotype on fasting total cholesterol (TC), (P=0.027), LDL-cholesterol (LDL-C), (P=0.008), and % LDL3 (P=0.001), with higher and lower levels in the E4 and E2 carriers respectively relative to the E3/E3 genotype. Reflective of a higher fasting TG (P=0.001), a significantly higher area under the curve for the postprandial TG response (TG AUC) was evident in the E4 carriers relative to the E3/E3 group (P=0.038). In the group as a whole, a significant age x genotype interaction was observed for fasting TC (P=0.021). In the participants >50 years there was a significant impact of genotype on TC (P=0.005), LDL-C (P=0.001) and TAG AUC (P=0.028).Conclusions: It is possible that an exaggerated postprandial lipaemia contributes to the increased coronary heart disease risk associated with carriers of the E4 allele; an effect which is more evident in older adults. (C) 2010 Elsevier Ireland Ltd. All rights reserved.