Trends in esophageal cancer and body mass index by race and gender in the state of Michigan.
Trends in esophageal cancer and body mass index by race and gender in the state of Michigan.
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DOI：
10.1186/1471-230x-9-47
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发表时间：
2009-06-23
影响因子：
2.4
通讯作者：
Fitzgerald TL
中科院分区：
文献类型：
--
作者：
Kort EJ;Sevensma E;Fitzgerald TL
在过去的几十年里，食道腺癌在美国的发病率一直在上升，尤其是在白人男性中。导致腺癌发病率的种族差异的因素尚不清楚。在这里，我们根据性别和种族来研究食管癌发病率和体重指数（BMI）的趋势。1985年至2005年年龄调整后的食管癌发病率是根据密歇根州癌症登记处收集的数据计算出来的。研究趋势与疾病控制中心管理的行为风险因素调查中获得的BMI数据趋势一起进行了分析。总体而言，1985年至2005年，密歇根州食管癌的年龄调整发病率从4.49例/10万人/年增加到4.72例/10万人/年。在白人男性中，腺癌的发病率每年增加0.21例/10万，1999年最高达到6.40例/10万，此后这些发病率保持不变。非裔美国男性的腺癌发病率有轻微但不显著的增加，其平均发病率比白人男性低8倍（0.58对4.72例/10万人年）。虽然密歇根州的平均BMI在上升（从1988年的26.68上升到2005年的30.33），但非裔美国人的平均BMI略高，而且非裔美国男性和白人男性的BMI增长速度没有差异。非裔美国男性和白人男性之间的差异不能用BMI的生态水平趋势来解释。需要进一步的研究来确定造成这种差异的因素，可能包括解剖脂肪分布。
Adenocarcinoma of the esophagus has been increasing in incidence in the U.S. over the past several decades, particularly among white males. The factors driving the racial disparity in adenocarcinomas rates are not well understood. Here we examine trends in both esophageal cancer incidence and body mass index (BMI) in a geographically defined cohort by gender and race. Age-adjusted esophageal cancer incidence rates from 1985 to 2005 were calculated from data collected by the Michigan state cancer registry. Trends were analyzed along with trends in BMI data obtained from the Behavioral Risk Factor Survey administered by the Centers for Disease Control. Overall, age adjusted incidence rates in esophageal carcinoma increased from 4.49 to 4.72 cases/100,000 persons per year in Michigan from 1985 to 2005. Among white males, the rate of adenocarcinomas increased by 0.21 cases/100,000 per year to a maximum of 6.40 cases/100,000 in 1999, after which these rates remained constant. There was a slight but non-significant increase in the rate of adenocarcinomas among African American males, for whom the average incidence rate was 8 times lower than that for white males (0.58 vs 4.72 cases/100,000 person years). While average BMI is rising in Michigan (from 26.68 in 1988 to 30.33 in 2005), average BMI was slightly higher among African Americans on average, and the rates of increase in BMI were not different between African American males and white males. The disparity between African American males and white males is not explained by ecological-level trends in BMI. Further research to identify the factors responsible for this disparity, possibly including anatomic fat distribution, are required.