Comparison of the roles of calcineurin in physiology and virulence in serotype D and serotype A strains of Cryptococcus neoformans
Comparison of the roles of calcineurin in physiology and virulence in serotype D and serotype A strains of Cryptococcus neoformans
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DOI：
10.1128/iai.68.2.982-985.2000
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发表时间：
2000-02-01
影响因子：
3.1
通讯作者：
Heitman, J
中科院分区：
文献类型：
--
作者：
Cruz, MC;Sia, RAL;Heitman, J
钙调神经磷酸酶基因的克隆和破坏血清型D菌株的新生隐球菌。血清型A和血清型D钙调神经磷酸酶突变体在37 ℃下是不活性的，并且在小鼠中是无毒的，而只有血清型A突变体是阳离子应激敏感的。因此，钙调神经磷酸酶在血清型A和血清型D菌株中发挥保守和不同的作用。
The calcineurin gene was cloned and disrupted in serotype D strains of Cryptococcus neoformans. Serotype A and serotype D calcineurin mutants were inviable at 37 degrees C and avirulent in mice, whereas only serotype A mutants were cation stress sensitive. Thus, calcineurin plays conserved and divergent roles in serotype A and serotype D strains.