A Meta-analysis of Gut Microbiota in Children with Autism
A Meta-analysis of Gut Microbiota in Children with Autism
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DOI：
10.1007/s10803-021-05002-y
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发表时间：
2021-05-05
影响因子：
3.9
通讯作者：
Ernesto Martinez-Gonzalez, Agustin
中科院分区：
文献类型：
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作者：
Andreo-Martinez, Pedro;Rubio-Aparicio, Maria;Ernesto Martinez-Gonzalez, Agustin
先前的研究报道了自闭症谱系障碍（ASD）儿童肠道微生物群（GM）的生态失调，这可能是通过微生物-肠道-脑轴影响儿童发育的一个决定性因素。然而，目前尚不清楚自闭症谱系障碍中是否存在一组特定的益生菌。本研究的目的是对分析自闭症儿童基因改造的研究进行荟萃分析。18项研究符合我们的选择标准。结果显示，ASD患儿链球菌（SMD+ = - 0.999; 95% CI - 1.549, - 0.449）和双歧杆菌属（SMD+ = - 0.513; 95% CI - 0.953, - 0.073）的相对丰度较低。总的来说，双歧杆菌属参与其中。然而，研究之间的差异可归因于报告偏差等因素。
Previous studies have reported dysbiosis in the gut microbiota (GM) of children with autism spectrum disorders (ASD), which may be a determining factor on child development through the microbiota-gut-brain axis. However, it is not clear if there is a specific group of dysbiotic bacteria in ASD. The aim of this study was to carry out a meta-analysis on the studies that analyze GM in children with ASD. 18 studies fulfilled our selection criteria. Our results showed a lower relative abundance of Streptococcus (SMD+ = - 0.999; 95% CI - 1.549, - 0.449) and Bifidobacterium genera (SMD+ = - 0.513; 95% CI - 0.953, - 0.073) in children with ASD. Overall, the Bifidobacterium genera is involved. However, differences found between studies are attributed to factors such as reporting bias.