Corpus callosum abnormalities in psychopathic antisocial individuals
Corpus callosum abnormalities in psychopathic antisocial individuals
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DOI：
10.1001/archpsyc.60.11.1134
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发表时间：
2003-11-01
影响因子：
--
通讯作者：
Colletti, P
中科院分区：
文献类型：
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作者：
Raine, A;Lencz, T;Colletti, P
背景：精神病态的反社会个体以前以半球间加工和胼胝体功能异常为特征，但尚未对这一群体的胼胝体结构特征进行研究。目的：评估(1)患有反社会人格障碍的精神病患者是否在胼胝体中表现出结构和功能障碍，(2)胼胝体结构维度测量与精神病之间的相关性反映了群体差异，(3)胼胝体异常与情感缺陷相关，(4)胼胝体异常与社会心理缺陷无关。设计：病例对照研究。设置：社区样本。参与者：15名反社会人格障碍和高精神病得分的男性和25名匹配的对照组，全部来自83名社区志愿者的更大样本。主要结果测量：胼胝体的结构磁共振成像测量（胼胝体白质的体积估计，厚度，长度，以及髋关节和脾脏面积），胼胝体功能测量（2个划分的视野任务），社会压力源时的皮肤电和心血管活动，情感和人际缺陷的人格测量，以及语言和空间能力。结果：与对照组相比，精神病性反社会个体胼胝体白质体积增加22.6% (P
Context: Psychopathic antisocial individuals have previously been characterized by abnormal interhemispheric processing and callosal functioning, but there have been no studies on the structural characteristics of the corpus callosum in this group.Objectives: To assess whether (1) psychopathic individuals with antisocial personality disorder show structural and functional impairments in the corpus callosum, (2) group differences are mirrored by correlations between dimensional measures of callosal structure and psychopathy, (3) callosal abnormalities are associated with affective deficits, and (4) callosal abnormalities are independent of psychosocial deficits.Design: Case-control study.Setting: Community sample.Participants: Fifteen men with antisocial personality disorder and high psychopathy scores and 25 matched, controls, all from a larger sample of 83 community volunteers.Main Outcome Measures: Structural magnetic resonance imaging measures of the corpus callosum (Volume estimate of callosal white matter, thickness, length, and genu and splenium area), functional callosal measures (2 divided visual field tasks), electrodermal and cardiovascular activity during a social stressor, personality measures of affective and interpersonal deficits, and verbal and spatial ability.Results: Psychopathic antisocial individuals compared with controls showed a 22.6% increase in estimated callosal white matter volume (P