Upregulation of transmembrane 4 L6 family member 1 predicts poor prognosis in invasive breast cancer: A STROBE-compliant article.
Upregulation of transmembrane 4 L6 family member 1 predicts poor prognosis in invasive breast cancer: A STROBE-compliant article.
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跨膜4 L6家族成员的上调预测侵入性乳腺癌的预后不良：符合频率的文章。
DOI：
10.1097/md.0000000000009476
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发表时间：
2017-12
期刊：
影响因子：
1.6
通讯作者：
Li J
中科院分区：
文献类型：
--
作者：
Xing P;Dong H;Liu Q;Zhao T;Yao F;Xu Y;Chen B;Zheng X;Wu Y;Jin F;Li J
跨膜4 L6家族成员1(TM4SF1)属于4-跨膜区家族，在多种人类肿瘤中发挥癌基因的作用。在这项工作中，我们旨在确定TM4SF1的表达及其对浸润性乳腺癌患者预后的影响。总体而言，我们招募了209名浸润性乳腺癌患者，并用免疫组织化学方法检测了肿瘤标本中TM4SF1的表达。分析TM4SF1的表达与乳腺癌患者临床病理参数及患者生存的关系。209例中，TM4SF1高表达137例(65.6%)。TM4SF1的高表达与晚期组织学分级、雌激素受体和孕激素受体阴性状态显著相关。三阴性乳腺癌(TNBC)肿瘤比非TNBC肿瘤更容易表达高水平的TM4SF1。TM4SF1高表达患者的无瘤生存期(DFS；P = .00)和总生存期(OS；P = .01)明显短于TM4SF1低表达患者。当仅对167例(79.9%)接受辅助化疗的患者进行生存分析时，TM4SF1的表达也与较差的DFS和OS相关(P = .00)。在多因素COX回归分析中，TM4SF1的表达仍是OS和DFS的独立预后指标。TM4SF1表达上调，可作为浸润性乳腺癌预后不良的独立指标。
Transmembrane 4 L6 family member 1 (TM4SF1) belongs to the 4-transmembrane-domain family and functions as an oncogene in multiple human cancers. In this work, we aim to determine TM4SF1 expression and its prognostic impact on patients with invasive breast cancer. Overall, we enrolled 209 invasive breast cancer patients and immunohistochemically examined the expression of TM4SF1 in tumor specimens. The relationship between TM4SF1 expression and clinicopathological parameter and patient survival of breast cancer patients was analyzed. Among the 209 cases, 137 (65.6%) exhibited high expression of TM4SF1. High TM4SF1 expression was significantly associated with advanced histological grade and negative estrogen receptor and progesterone receptor status. Triple-negative breast cancer (TNBC) tumors were more likely to express high levels of TM4SF1 than non-TNBC cases. Patients with high tumoral expression of TM4SF1 had a significantly shorter disease-free survival (DFS; P = .00) and overall survival (OS; P = .01) than those with low expression of TM4SF1. When survival analysis was restricted to the 167 patients (79.9%) receiving adjuvant chemotherapy, TM4SF1 expression was also correlated with poorer DFS and OS (P = .00). In multiple Cox regression analysis TM4SF1 expression remained an independent prognostic indicator for OS and DFS. TM4SF1 is upregulated and serves as an independent poor prognostic indicator in invasive breast cancer.