RELATION OF BODY-FAT PATTERNING TO LIPID AND LIPOPROTEIN CONCENTRATIONS IN CHILDREN AND ADOLESCENTS - THE BOGALUSA HEART-STUDY
RELATION OF BODY-FAT PATTERNING TO LIPID AND LIPOPROTEIN CONCENTRATIONS IN CHILDREN AND ADOLESCENTS - THE BOGALUSA HEART-STUDY
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DOI：
10.1093/ajcn/50.5.930
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发表时间：
1989-11-01
影响因子：
7.1
通讯作者：
BERENSON, GS
中科院分区：
文献类型：
--
作者：
FREEDMAN, DS;SRINIVASAN, SR;BERENSON, GS
虽然成人脂肪组织的躯干分布与几种代谢并发症有关，但其在生命早期的重要性却很少受到关注。因此，在361名6 - 18岁的儿童中检查了几种人体测量方法与血脂、脂蛋白和载脂蛋白浓度的关系。（之前选择儿童是因为极低密度脂蛋白胆固醇和低密度脂蛋白胆固醇的极端水平。分析显示了两组人体测量变量：躯干测量（腰围和肩胛下，肋下，髂上皮褶厚度）和外周皮褶厚度（股骨，三头肌，小腿，二头肌）。在校正了两种胆固醇浓度高的儿童的全身性肥胖后，与脂蛋白胆固醇浓度低的儿童相比，躯干脂肪更多，但外周脂肪更少。躯干脂肪模式也与高密度脂蛋白胆固醇和载脂蛋白A-1浓度降低有关。脂肪模式的知识可能有助于识别容易患高脂血症的人。
Although a truncal distribution of adipose tissue in adults is associated with several metabolic complications, its importance in early life has received little attention. The relation of several anthropometric measures to serum concentrations of lipids, lipoproteins, and apolipoproteins was therefore examined in 361 children who were between ages 6 and 18 y. (Children had been selected previously because of extreme levels of very-low-density- and low-density-lipoprotein cholesterol.) Analyses revealed two groups of anthropometric variables: truncal measures (waist circumference and subscapular, subcostal, and suprailiac skinfold thicknesses) and thickness of peripheral skinfolds (femoral, triceps, calf, and biceps). After generalized obesity was adjusted for children with high concentration of both cholesterol fractions had more truncal fat but less peripheral fat than did children with low lipoprotein cholesterol concentrations. A truncal fat pattern was also associated with decreased concentrations of high-density-lipoprotein cholesterol and apolipoprotein A-1. Knowledge of fat patterning may help identify persons prone to hyperlipidemia.