Tyrosol is a quorum-sensing molecule in Candida albicans
Tyrosol is a quorum-sensing molecule in Candida albicans
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DOI：
10.1073/pnas.0401416101
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发表时间：
2004-04-06
影响因子：
11.1
通讯作者：
Fink, GR
中科院分区：
文献类型：
--
作者：
Chen, H;Fujita, M;Fink, GR
人类真菌病原体白色念珠菌在稀释到新鲜的最低限度的培养基中时，显示出明显的生长滞后。通过添加来自高密度培养的条件培养基来消除这一滞后。条件培养液的活性成分是酪醇，在生长过程中不断释放到培养液中。在允许形成芽管的条件下，酪醇刺激这些丝状突起的形成。由于另一种群体感应分子法尼醇抑制芽管的形成，这一过程必须受到复杂的环境条件的正负控制。酪醇作为一种自我调节分子的鉴定对假丝酵母菌的生长和形态发生动力学有着重要的意义。
The human fungal pathogen Candida albicans shows a significant lag in growth when diluted into fresh minimal medium. This lag is abolished by the addition of conditioned medium from a high-density culture. The active component of conditioned medium is tyrosol, which is released into the medium continuously during growth. Under conditions permissive for germ-tube formation, tyrosol stimulates the formation of these filamentous protrusions. Because germ-tube formation is inhibited by farnesol, another quorum-sensing molecule, this process must be under complex positive and negative control by environmental conditions. The identification of tyrosol as an autoregulatory molecule has important implications on the dynamics of growth and morphogenesis in Candida.