Effects of piracetam on membrane fluidity in the aged mouse, rat, and human brain.
Effects of piracetam on membrane fluidity in the aged mouse, rat, and human brain.
复制标题
吡拉西坦对老年小鼠、大鼠和人脑膜流动性的影响。
DOI：
10.1016/s0006-2952(96)00463-7
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发表时间：
1997
影响因子：
5.8
通讯作者：
R. Bartsch
中科院分区：
文献类型：
--
作者：
W. Müller;S. Koch;K. Scheuer;A. Rostock;R. Bartsch
体外预孵育老年小鼠脑细胞膜，发现吡拉西坦（0.1-1.0 mmol/L）可增强脑细胞膜的流动性，表现为膜结合荧光探针1，6-二苯基-1，3，5-己三烯（DPH）的各向异性降低。吡拉西坦在体外对老年大鼠和人类的脑细胞膜有类似的作用，但它不会改变年轻小鼠脑细胞膜的流动性。用吡拉西坦（300 mg/kg，每日一次）长期给药年轻和老年大鼠，可显著增加老年动物某些脑区的膜流动性，但对年轻大鼠的膜流动性无可测量的影响。相同的治疗显着改善主动回避学习的老年大鼠。有人建议，吡拉西坦的药理学性质的一些可以解释其对膜流动性的影响。
In vitro preincubation of brain membranes of aged mice wirh piracetam (0.1–1.0 mmol/L) enhanced membrane fluidity, as indicated by decreased anisotropy of the membrane-bound fluorescence probe 1,6-diphenyl-1,3,5-hexatriene (DPH). Piracetam had similar in vitro effects on brain membranes of aged rats and humans, but it did not alter brain membrane fluidity in young mice. Chronic treatment of young and aged rats with piracetam (300 mg/kg once daily) significantly increased membrane fluidity in some brain regions of the aged animals, but had no measurable effect on membrane fluidity in the young rats. The same treatment significantly improved active avoidance learning in the aged rats only. It is suggested that some of the pharmacological properties of piracetam can be explained by its effects on membrane fluidity.