Prescribing trends of gabapentin, pregabalin, and oxycodone: a secondary analysis of primary care prescribing patterns in England.
Prescribing trends of gabapentin, pregabalin, and oxycodone: a secondary analysis of primary care prescribing patterns in England.
复制标题
DOI：
10.3399/bjgpopen19x101662
复制
发表时间：
2019-10-01
期刊：
影响因子：
--
通讯作者：
Pinder, Richard J
中科院分区：
文献类型：
--
作者：
Green, Katlyn;Cooke O'Dowd, Nora;Pinder, Richard J
背景：使用和滥用加巴喷丁、普瑞巴林和羟考酮等处方药造成医源性伤害的风险很大。近年来，英国与这些药物相关的死亡有所增加。 目的：描述英国加巴喷丁、普瑞巴林和羟考酮（称为依赖性形成药物 (DFM)）的一般实践处方趋势，并描述不必要变化的潜在驱动因素（即非常高的处方）。 设计和背景：本研究是对来自与初级保健人口统计和相关来源的开源、公开的政府数据进行的回顾性二次分析。方法：本研究使用连续 5 年（2013 年 4 月至 2018 年 3 月）的汇总数据来调查处方的纵向趋势以及实践和临床委托组 (CCG) 层面的处方趋势变化。结果：在此期间，加巴喷丁、普瑞巴林和羟考酮的年度处方量逐年增加。处方趋势的变化与全科医生执业剥夺五分位数相关，其中最贫困的全科医生执业比例为 313%（P
BACKGROUND: The risk of iatrogenic harm from the use and misuse of prescription drugs such as gabapentin, pregabalin, and oxycodone is substantial. In recent years, deaths associated with these drugs in England have increased.AIM: To characterise general practice prescribing trends for gabapentin, pregabalin, and oxycodone - termed dependence forming medicines (DFM) - in England and describe potential drivers of unwarranted variation (that is, very high prescribing).DESIGN & SETTING: This study is a retrospective secondary analysis of open source, publicly available government data from various sources pertaining to primary care demographics and prescriptions.METHOD: This study used 5 consecutive years (April 2013-March 2018) of aggregate data to investigate longitudinal trends of prescribing and variation in prescribing trends at practice and clinical commissioning group (CCG) level.RESULTS: Annual prescriptions of gabapentin, pregabalin, and oxycodone increased each year over the period. Variation in prescribing trends was associated with GP practice deprivation quintile, where the most deprived GP practices prescribed 313% (P