Dual fate of subplate neurons in a rodent.
Dual fate of subplate neurons in a rodent.
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DOI：
10.1093/cercor/1.5.433
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发表时间：
1991-09
期刊：
影响因子：
3.7
通讯作者：
T. Woo;J. M. Beale;B. Finlay
中科院分区：
文献类型：
--
作者：
T. Woo;J. M. Beale;B. Finlay
虽然亚板神经元在迄今已被研究的其他哺乳动物物种的大脑皮层发育过程中丢失，但在啮齿类动物中，亚板(交替被称为VIB或VII层)至少部分地持续到成年。我们用两种方法追踪了金黄地鼠脑底核的发育过程。我们首先使用氚胸苷标记来追踪亚板、VI层和LGN中已识别的细胞队列数量的相对变化。我们还估计了从发育早期到成年，大脑皮质第VI层与亚板中的细胞总数。这些方法显示亚板细胞损失率很高，介于50%到80%之间，但在成年后明显保留了相当一部分早期生成的细胞作为可识别的层。皮质神经发生的时间和亚板中细胞的相对损失量的物种差异可以更好地描述该区域的发育功能。
While subplate neurons are lost in the development of the cerebral cortex of other mammalian species that have so far been investigated, in rodents the subplate (alternately termed layer VIb or VII) persists to adulthood, at least in part. We traced the developmental course of the subplate in the golden hamster, using two methods. We first used tritiated thymidine labeling to trace relative changes in the numbers of identified cohorts of cells in the subplate, layer VI, and the LGN. We also estimated the total number of cells in the subplate versus layer VI of the cortex from early in development to adulthood. These methods showed a high rate of cell loss in the subplate, between 50% and 80%, but with the clear retention of a substantial fraction of this early-generated population as a recognizable layer in adulthood. Species variations in the timing of cortical neurogenesis and the relative amount of cell loss in the subplate can be used to better describe the developmental function of this region.