KDIGO Clinical Practice Guideline on the Evaluation and Management of Candidates for Kidney Transplantation
KDIGO Clinical Practice Guideline on the Evaluation and Management of Candidates for Kidney Transplantation
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DOI：
10.1097/tp.0000000000003136
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发表时间：
2020-04-01
期刊：
影响因子：
6.2
通讯作者：
Knoll, Gregory A.
中科院分区：
文献类型：
--
作者：
Chadban, Steven J.;Ahn, Curie;Knoll, Gregory A.
《2020肾脏疾病：改善全球结果（KDIGO）肾移植候选人评估和管理临床实践指南》旨在帮助全球卫生保健专业人员评估和管理潜在的已故或活体供体肾移植候选人。本指南涉及一般候选问题，如获得移植、患者人口统计和健康状况因素以及免疫和心理社会评估。各种风险因素和合并症对个体移植适宜性的影响，如依从性、吸烟、糖尿病、肥胖、围手术期问题、肾衰竭的原因、感染、恶性肿瘤、肺部疾病、心脏和外周动脉疾病、神经系统疾病、胃肠道和肝脏疾病、血液疾病以及骨骼和矿物质疾病。本指南提供了评估候选人个人资料的建议，以便单独考虑每个风险因素和合并症。目的是帮助临床团队吸收与个体相关的所有数据，在其当地健康背景下考虑这些数据，并对移植的候选性做出总体判断。指南制定过程遵循推荐评估、制定和评价分级（GRADE）方法。指南建议主要基于对相关研究的系统回顾和我们对证据质量的评估，并提供了建议的优势。讨论了证据的局限性，指出了与以往指南的不同之处，并提出了对未来研究的建议。
The 2020 Kidney Disease: Improving Global Outcomes (KDIGO) Clinical Practice Guideline on the Evaluation and Management of Candidates for Kidney Transplantation is intended to assist health care professionals worldwide who evaluate and manage potential candidates for deceased or living donor kidney transplantation. This guideline addresses general candidacy issues such as access to transplantation, patient demographic and health status factors, and immunological and psychosocial assessment. The roles of various risk factors and comorbid conditions governing an individual's suitability for transplantation such as adherence, tobacco use, diabetes, obesity, perioperative issues, causes of kidney failure, infections, malignancy, pulmonary disease, cardiac and peripheral arterial disease, neurologic disease, gastrointestinal and liver disease, hematologic disease, and bone and mineral disorder are also addressed. This guideline provides recommendations for evaluation of individual aspects of a candidate's profile such that each risk factor and comorbidity are considered separately. The goal is to assist the clinical team to assimilate all data relevant to an individual, consider this within their local health context, and make an overall judgment on candidacy for transplantation. The guideline development process followed the Grades of Recommendation Assessment, Development, and Evaluation (GRADE) approach. Guideline recommendations are primarily based on systematic reviews of relevant studies and our assessment of the quality of that evidence, and the strengths of recommendations are provided. Limitations of the evidence are discussed with differences from previous guidelines noted and suggestions for future research are also provided.