Blood-stage dynamics and clinical implications of mixed Plasmodium vivax-Plasmodium falciparum infections
Blood-stage dynamics and clinical implications of mixed Plasmodium vivax-Plasmodium falciparum infections
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DOI：
10.4269/ajtmh.1999.61.367
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发表时间：
1999-09-01
影响因子：
3.3
通讯作者：
McKenzie, FE
中科院分区：
文献类型：
--
作者：
Mason, DP;McKenzie, FE
We present a mathematical model of the blood-stage dynamics of mixed Plasmodium vivax-Plasmodium falciparum malaria infections in humans. The model reproduces features of such infections found in nature and suggests several phenomena that may merit clinical attention, including the potential recrudescence of a long-standing, low-level P. falciparum infection following a P. vivax infection or relapse and the capacity of an existing P. vivax infection to reduce the peak parasitemia of a P. falciparum superinfection. We simulate the administration of antimalarial drugs, and illustrate some potential complications in treating mixed-species malaria infections. Notably, our model indicates that when a mixed-species infection is misdiagnosed as a single-species P. vivax infection, treatment for P. vivax can lead to a surge in P. falciparum parasitemia.
