Normal human left and right ventricular and left atrial dimensions using steady state free precession magnetic resonance imaging
Normal human left and right ventricular and left atrial dimensions using steady state free precession magnetic resonance imaging
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DOI：
10.1080/10976640500295516
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发表时间：
2005-01-01
影响因子：
6.4
通讯作者：
Neubauer, S
中科院分区：
文献类型：
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作者：
Hudsmith, LE;Petersen, SE;Neubauer, S
目的。该项目的目的是使用稳态自由进动心脏磁共振成像（临床选择的技术）在广泛的年龄范围内建立健康志愿者左心室、右心室和左心房尺寸的数据库。方法。 108 名健康志愿者（63 名男性，45 名女性）使用稳态自由进动序列进行了心脏磁共振成像。手动分析由 2 名经验丰富的观察员进行。结果。男性的左右心室容积以及左心室质量均大于女性：左心室舒张末期容积为 160 +/- 29 mL 与 135 +/- 26 mL，左心室收缩末期容积为 50 +/- 16 mL 与 42 +/- 12 mL； RV 舒张末期容量 190 +/- 33 mL 与 148 +/- 35 mL，RV 收缩末期容量 78 +/- 20 mL 与 56 +/- 18 mL（全部 p < .05）。将值标准化为体表面积消除了左心室体积的统计差异，但没有消除左心室质量或右心室体积的统计差异。随着年龄的增长，男性双侧心室的体积和质量指数显着下降，而女性则保持不变。与女性相比，男性的最大左心房容积（103 +/- 30 mL vs. 89 +/- 21 mL，p = .01）和左心房每搏输出量（5.8 +/- 23 mL vs. 48 +/- 15 mL，p = .01）显着更大。两性之间的左心房射血分数没有差异。结论。我们建立了一个大型数据库，其中包含男性和女性左心室、右心室功能以及左心房功能与年龄相关的正常范围。这将有助于准确解释临床和研究数据集。
Purpose. The aim of this project was to establish a database of left and right ventricular and left atrial dimensions in healthy volunteers using steady-state free precession cardiac magnetic resonance imaging, the clinical technique of choice, across a wide age range. Methods. 108 healthy volunteers (63 male, 45 female) underwent cardiac magnetic resonance imaging using steady-state free precession sequences. Manual analysis was performed by 2 experienced observers. Results. Left and right ventricular volumes and left ventricular mass were larger in males than females: LV end-diastolic volume 160 +/- 29 mL vs. 135 +/- 26 mL, LV end-systolic volume 50 +/- 16 mL vs. 42 +/- 12 mL; RV end-diastolic volume 190 +/- 33 mL vs. 148 +/- 35 mL, RV end-systolic volume 78 +/- 20 mL vs. 56 +/- 18 mL (p < .05 for all). Normalization of values to body surface area removed the statistical differences for LV volumes, but not for LV mass or RV volumes. With increased age, males showed a significant decrease in volume and mass indices for both ventricles, while female values remained unchanged. Compared to females, males had significantly larger maximal left atrial volumes (103 +/- 30 mL vs. 89 +/- 21 mL, p = .01) and left atrial stroke volumes (5.8 +/- 23 mL vs. 48 +/- 15 mL, p = .01). There was no difference in left atrial ejection fraction between the sexes. Conclusion. We have produced a large database of age-related normal ranges for left and right ventricular function and left atrial function in males and females. This will allow accurate interpretation of clinical and research datasets.