Malaria in pregnancy before and after the implementation of a national IPTp program in Gabon
Malaria in pregnancy before and after the implementation of a national IPTp program in Gabon
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DOI：
10.4269/ajtmh.2007.77.418
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发表时间：
2007-09-01
影响因子：
3.3
通讯作者：
Kremsner, Peter G.
中科院分区：
文献类型：
--
作者：
Ramharter, Michael;Schuster, Katharina;Kremsner, Peter G.
许多非洲国家最近采用了磺胺嘧啶-乙胺嘧啶的间歇性妊娠期预防性治疗，以减少与妊娠期疟疾有关的孕产妇和新生儿发病率和死亡率。我们评估了加蓬新设立的国家IPTp计划对孕产妇和新生儿健康的影响。孕产妇恶性疟原虫感染，贫血，早产和出生体重的患病率数据收集在加蓬城市和农村地区的横断面调查之前和之后，共1 403名妇女及其后代实施的IPTp。在引入IPTp后，母体恶性疟原虫感染率显著下降（危险比0.16，P < 0.001）。虽然观察到对孕妇贫血率的影响不大，但对遵守国家建议的妇女来说，低出生体重和早产的发生率有明显的好处。这些影响在初次和二次妊娠妇女中最为明显。
Intermittent preventive treatment in pregnancy (IPTp) with sulfadoxine-pyrimethamine has recently been adopted by many African countries to reduce maternal and neonatal morbidity and mortality associated with malaria in pregnancy. We assessed the impact of a newly established national IPTp program on maternal and neonatal health in Gabon. Data on prevalence of maternal Plasmodium falciparum infection, anemia, premature birth, and birth weight were collected in cross-sectional surveys in urban and rural regions of Gabon before and after the implementation of IPTp in a total of 1403 women and their offspring. After introduction of IPTp, the prevalence of maternal Plasmodium falciparum infection decreased dramatically (risk ratio 0.16, P < 0.001). Whereas only a modest effect on the rate of anemia in pregnant women was observed, there was a marked benefit on the prevalence of low birth weight and premature birth for women adhering to national recommendations. These effects were most pronounced in primi- and secundigravid women.