The Expression of PEDF and its Putative Receptors in Hepatocellular Carcinoma and Background Liver Tissue
The Expression of PEDF and its Putative Receptors in Hepatocellular Carcinoma and Background Liver Tissue
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DOI：
10.21873/anticanres.14877
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发表时间：
2021-03-01
影响因子：
2
通讯作者：
Yano, Hirohisa
中科院分区：
文献类型：
--
作者：
Akiba, Jun;Yoshida, Takafumi;Yano, Hirohisa
背景/目的：肝细胞癌（HCC）仍然是最大的医学问题之一。色素上皮衍生因子（PEDF）是一种糖蛋白，属于丝氨酸蛋白酶抑制剂超家族。PEDF与其两种受体，脂肪甘油三酯脂肪酶（ATGL）和层粘连蛋白受体（LR）相互作用。材料和方法：对151例HCC及其癌旁肝组织进行PEDF、LR和ATGL免疫组化染色。结果如下：肝细胞癌中LR高表达与高组织学分级和门静脉浸润有关，而PEDF高表达与无门静脉浸润有关。背景肝脏中LR的高表达与低血清白蛋白水平在统计学上相关，并且是预后不良的独立预后因素。背景肝组织中脂肪变性超过5%的病例均未显示PEDF高表达。结论：PEDF/LR/ATGL可作为HCC和各种慢性肝病的潜在生物标志物。
Background/Aim: Hepatocellular carcinoma (HCC) remains one of the biggest medical issues. Pigment epithelial derived factor (PEDF) is a glycoprotein that belongs to the superfamily of serine protease inhibitors. PEDF interacts with its two receptors, adipose triglyceride lipase (ATGL) and laminin receptor (LR). Materials and Methods: We conducted immunohistochemical staining for PEDF, LR and ATGL in 151 resected HCCs and their background liver tissues. Results: High expression of LR in HCC was associated with high histological grade and portal vein invasion, while high expression of PEDF in HCC was associated with absence of portal vein invasion. High LR expression in background liver was statistically associated with low serum albumin levels and was an independent prognostic factor of worse outcomes. No cases with more than 5% fatty degeneration in the background liver tissue showed high PEDF expression. Conclusion: PEDF/LR/ATGL could be potential biomarkers in HCC and various chronic hepatic disorders.