Catalytic Amide Allylation of Alpha-ketoester: Extremely High Enantioselective Synthesis of ester functionalised alpha-methylene gamma-butyrolactones
Catalytic Amide Allylation of Alpha-ketoester: Extremely High Enantioselective Synthesis of ester functionalised alpha-methylene gamma-butyrolactones
复制标题
α-酮酯的催化酰胺烯丙基化：酯官能化 α-亚甲基 γ-丁内酯的极高对映选择性合成
DOI：
10.1039/c4ob01508h
复制
发表时间：
2014
影响因子：
3.2
通讯作者：
and Hidemi Yoda
中科院分区：
文献类型：
--
作者：
Masaki Takahashi;Yusuke Murata;Masahiro Ishida;Fumitoshi Yagishita;Masami Sakamoto;Tetsuya Sengoku;and Hidemi Yoda
该通讯报道了一种新的催化酰胺烯丙基化为无环α-酮酯体系的重大突破，实现了令人满意的高产率和极高水平的不对称诱导，从而允许高度对映选择性合成酯官能化的α-亚甲基-γ-丁内酯。
This communication reports a significant breakthrough on the novel catalytic amide allylation to the acyclic α-ketoester systems, achieving satisfactorily high yields and extremely high levels of the asymmetric induction to allow for highly enantioselective synthesis of ester functionalised α-methylene-γ-butyrolactones.