Drosophila miniature and dusky encode ZP proteins required for cytoskeletal reorganisation during wing morphogenesis
Drosophila miniature and dusky encode ZP proteins required for cytoskeletal reorganisation during wing morphogenesis
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DOI：
10.1242/jcs.00298
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发表时间：
2003-04-01
影响因子：
4
通讯作者：
Akam, M
中科院分区：
文献类型：
--
作者：
Roch, F;Alonso, CR;Akam, M
我们已经描述了两个果蝇基因的功能，微型和暗色，这是在翅膀表皮分化过程中顶膜的形态重组所必需的。这些基因编码含有ZP(透明带)结构域的跨膜蛋白，并与一些脊椎动物和无脊椎动物的顶端基质成分同源。微型蛋白和暗色蛋白仅在分泌角质层的组织中表达，Min蛋白在角质层形成的早期阶段定位于顶膜。我们认为Min和Dusky在ZP结构域蛋白中形成了一个新的亚家族，并且特异性地参与了顶膜、细胞骨架和形成的角质层之间的相互作用。
We have characterised the function of two Drosophila genes, miniature and dusky, that are required for the morphological reorganisation of the apical membrane during wing epidermis differentiation. These genes encode transmembrane proteins containing a ZP (zona pellucida) domain and are homologous to several vertebrate and invertebrate apical matrix components. miniature and dusky are only expressed in tissues secreting a cuticle, and the Min protein localises to the apical membrane during the early stages of cuticle formation. We propose that Min and Dusky form a novel subfamily within the ZP domain proteins and are specifically involved in the interactions between the apical membrane, the cytoskeleton and the forming cuticle.