Nucleosome Remodeling and Epigenetics
Nucleosome Remodeling and Epigenetics
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DOI：
10.1101/cshperspect.a017905
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发表时间：
2013-09-01
影响因子：
7.2
通讯作者：
Workman, Jerry L.
中科院分区：
文献类型：
--
作者：
Becker, Peter B.;Workman, Jerry L.
真核细胞染色质通过所谓的“核小体重塑”ATP酶家族的作用保持灵活和动态以响应环境、代谢和发育线索。与它们的解旋酶祖先一致，这些酶在结合和水解ATP时经历构象变化。同时，它们与DNA和组蛋白相互作用，从而改变靶核小体中的组蛋白-DNA相互作用。它们的作用可能导致核小体的完全或部分解体、组蛋白与变体的交换、核小体的组装或组蛋白八聚体在DNA上的移动。“重塑”可以使DNA序列与相互作用的蛋白质接触，或者相反，促进包装成紧密折叠的结构。重塑过程参与基因组功能的各个方面。重塑活动通常与其他机制如组蛋白修饰或RNA代谢整合，以组装稳定的表观遗传状态。
Eukaryotic chromatin is kept flexible and dynamic to respond to environmental, metabolic, and developmental cues through the action of a family of so-called "nucleosome remodeling" ATPases. Consistent with their helicase ancestry, these enzymes experience conformation changes as they bind and hydrolyze ATP. At the same time they interact with DNA and histones, which alters histone-DNA interactions in target nucleosomes. Their action may lead to complete or partial disassembly of nucleosomes, the exchange of histones for variants, the assembly of nucleosomes, or the movement of histone octamers on DNA. "Remodeling" may render DNA sequences accessible to interacting proteins or, conversely, promote packing into tightly folded structures. Remodeling processes participate in every aspect of genome function. Remodeling activities are commonly integrated with other mechanisms such as histone modifications or RNA metabolism to assemble stable, epigenetic states.