A downy mildew effector evades recognition by polymorphism of expression and subcellular localization
A downy mildew effector evades recognition by polymorphism of expression and subcellular localization
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DOI：
10.1038/s41467-018-07469-3
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发表时间：
2018-12-05
影响因子：
16.6
通讯作者：
Jones, Jonathan D. G.
中科院分区：
文献类型：
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作者：
Asai, Shuta;Furzer, Oliver J.;Jones, Jonathan D. G.
病原体与植物的共同进化涉及逃避宿主监视系统的选择。卵菌透明霜霉（Hyaloperonospora arabidopsidis，Hpa）引起拟南芥霜霉病，拟南芥种质与Hpa分离物之间的小种特异性相互作用符合基因对基因模型，即寄主的抗性或易感性由植物抗性（R）基因和病原体无毒（AVR）基因的配对决定。拟南芥Col-0携带R基因RPP 4，该基因赋予对Hpa分离物Ephy 2和Emwa 1的抗性，但其同源识别的效应子未知。在这里，我们报告的识别RPP 4和显示耐药破坏分离株的HPA对RPP 4的拟南芥携带的等位基因，要么不表达，或显示细胞质，而不是核亚细胞定位识别的AVRY 2 AVR效应基因。
Pathogen co-evolution with plants involves selection for evasion of host surveillance systems. The oomycete Hyaloperonospora arabidopsidis (Hpa) causes downy mildew on Arabidopsis, and race-specific interactions between Arabidopsis accessions and Hpa isolates fit the genefor-gene model in which host resistance or susceptibility are determined by matching pairs of plant Resistance (R) genes and pathogen Avirulence (AVR) genes. Arabidopsis Col-0 carries R gene RPP4 that confers resistance to Hpa isolates Emoy2 and Emwa1, but its cognate recognized effector(s) were unknown. We report here the identification of the Emoy2 AVR effector gene recognized by RPP4 and show resistance-breaking isolates of Hpa on RPP4-containing Arabidopsis carry the alleles that either are not expressed, or show cytoplasmic instead of nuclear subcellular localization.