Sensitization of Rh-negative daughters by their Rh-positive mothers.
Sensitization of Rh-negative daughters by their Rh-positive mothers.
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Rh 阴性女儿被 Rh 阳性母亲致敏。
DOI：
10.1056/nejm196703092761004
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发表时间：
1967
期刊：
影响因子：
--
通讯作者：
J. Taylor
中科院分区：
文献类型：
--
作者：
J. Taylor
Burnett 和 Fenner1 对免疫耐受的预测表明，Rh 阳性母亲所生的 Rh 阴性女孩可能会诱导对 Rh 抗原的耐受。2 免疫耐受被认为是可能的，因为至少在某些妊娠中，母体红细胞会穿过胎盘到达胎儿。3 4 5 6 相反的观点认为，在没有接受过已知刺激的母亲的第一胎婴儿中，少数经证实的溶血病病例可能是由于母体获得的敏化所致。母亲在子宫内。7, 8 这项研究的目的是确定 Rh 阳性母亲是否会诱导其 Rh 阴性女儿产生免疫耐受或原发性致敏。 。 。
THE prediction of immunologic tolerance by Burnett and Fenner1 suggested that tolerance to the Rh antigen might be induced in Rh-negative girls born of Rh-positive mothers.2 Immunologic tolerance was considered possible because maternal red cells cross the placenta to the fetus in at least some pregnancies.3 4 5 6 A contrary opinion held that the few authenticated cases of hemolytic disease, in first-born infants of mothers who had received no known stimulus, might be due to sensitization acquired by the mother in utero.7 , 8 This study was undertaken to determine whether Rh-positive mothers induce immunologic tolerance or primary sensitization in their Rh-negative daughters . . .