The Addenbrooke's Cognitive Examination Revised (ACE-R): a brief cognitive test battery for dementia screening
The Addenbrooke's Cognitive Examination Revised (ACE-R): a brief cognitive test battery for dementia screening
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DOI：
10.1002/gps.1610
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发表时间：
2006-11-01
影响因子：
4
通讯作者：
Hodges, John R.
中科院分区：
文献类型：
--
作者：
Mioshi, Eneida;Dawson, Kate;Hodges, John R.
有一个明确的需要简短的，但敏感和具体的，认知筛查工具的普及所证明的Addenbrooke的认知Examination（ACE）.Objectives我们的目的是验证一个改进的修订版（ACE-R），其中包括五个子域分数（方向/注意力，记忆，语言流畅性，语言和视觉空间）。共241名受试者参加了这项研究（阿尔茨海默病=67，额颞叶痴呆=55，路易体痴呆=20，轻度认知障碍MCI =36，对照=63）。与临床痴呆量表相关显著（r=-0.321，p < 0.001）。定义了两个临界值（88：灵敏度=0.94，特异性=0.89; 82：灵敏度=0.84，特异性=1.0）。在88和82之间的分数产生痴呆的似然比：在82的截止值，痴呆的可能性是100：1。个别年龄和教育匹配组的MCI，AD和对照组的比较，MCI组的控制和AD之间的性能，并透露MCI患者被损害的领域以外的记忆（注意力/方向，语言流畅性和语言）。结论ACE-R完成标准的有效的痴呆症筛查测试，敏感的早期认知功能障碍。版权所有（c）2006约翰威利父子有限公司。
There is a clear need for brief, but sensitive and specific, cognitive screening instruments as evidenced by the popularity of the Addenbrooke's Cognitive Examination (ACE).Objectives We aimed to validate an improved revision (the ACE-R) which incorporates five sub-domain scores (orientation/attention, memory, verbal fluency, language and visuo-spatial).Methods Standard tests for evaluating dementia screening tests were applied. A total of 241 subjects participated in this study (Alzheimer's disease =67, frontotemporal dementia =55, dementia of Lewy Bodies =20; mild cognitive impairment-MCI =36; controls =63).Results Reliability of the ACE-R was very good (alpha coefficient=0.8). Correlation with the Clinical Dementia Scale was significant (r=-0.321, p < 0.001). Two cut-offs were defined (88: sensitivity =0.94, specificity =0.89; 82: sensitivity =0.84, specificity=1.0). Likelihood ratios of dementia were generated for scores between 88 and 82: at a cut-off of 82 the likelihood of dementia is 100: 1. A comparison of individual age and education matched groups of MCI, AD and controls placed the MCI group performance between controls and AD and revealed MCI patients to be impaired in areas other than memory (attention/orientation, verbal fluency and language).Conclusions The ACE-R accomplishes standards of a valid dementia screening test, sensitive to early cognitive dysfunction. Copyright (c) 2006 John Wiley & Sons, Ltd.