Effects of Ketamine on Low Intensity Tactile Sensory Input Are Not Dependent upon a Spinal Site of Action
Effects of Ketamine on Low Intensity Tactile Sensory Input Are Not Dependent upon a Spinal Site of Action
复制标题
氯胺酮对低强度触觉输入的影响不依赖于脊柱作用部位
DOI：
10.1213/00000539-198611000-00005
复制
发表时间：
1986
影响因子：
5.7
通讯作者：
J. G. Collins
中科院分区：
文献类型：
--
作者：
J. G. Collins
The development of a technique for studying spinal dorsal horn electrophysiology in intact, awake, drug-free cats enables the study of spinal sites and mechanisms of action of anesthetic and analgesic agents in a system that more closely reflects normal physiology. Using this technique, we re-evaluated the effect of ketamine on spinal dorsal horn sensory transmission. The results of our study confirm previous work done in acute preparations. Ketamine (maximum dose 20 mg/kg) did not significantly reduce the response of low threshold (n = 11) dorsal horn neurons to low intensity sensory stimulation. However, that same dose of ketamine did suppress noxiously evoked activity of the two wide dynamic range neurons encountered in the study, while having a varied effect on neurons responsive to proprioceptive input (n = 7). These findings confirm that, in the intact animal with all modulatory systems intact, ketamine “dissociation” of low intensity tactile stimuli does not appear to involve a spinal mechanism of action. The results also support the importance of spinal sites of action for the analgesia produced by ketamine, as well as the importance of distinguishing between the anesthetic and analgesic effects of that drug.
