Oncogenicity of murine mammary tumor virus produced in tissue culture: brief communication.
Oncogenicity of murine mammary tumor virus produced in tissue culture: brief communication.
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组织培养中产生的鼠乳腺肿瘤病毒的致癌性：简要交流。
DOI：
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发表时间：
1978
期刊：
影响因子：
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通讯作者：
P. Bentvelzen
中科院分区：
文献类型：
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作者：
L. Arthur;D. Fine;P. Bentvelzen
小鼠乳腺肿瘤病毒（MuMTV）是从糖皮质激素刺激的C3 H小鼠乳腺癌细胞系中产生的，不含小鼠白血病病毒，对断奶BALB/c小鼠具有致癌性。早在接种后136天，MuMTV就诱导了腺癌，病毒颗粒低至5 × 10（3）个/小鼠。肿瘤发生率与病毒剂量无直接相关性;相反，在较高MuMTV浓度（1.2 × 10（8）个颗粒/小鼠）时较低，在1.3 × 10（5）个颗粒/小鼠时达到最佳，并随病毒稀释而降低。
Murine mammary tumor virus (MuMTV), produced from a glucocorticoid-stimulated C3H mouse mammary adenocarcinoma cell line, was free of murine leukemia virus and oncogenic for weanling BALB/c mice. Adenocarcinomas were induced by MuMTV as early as 136 days post inoculation and with as low as 5 X 10(3) virus particles/mouse. Tumor incidence did not correlate directly with virus dose; rather, it was low at higher MuMTV concentrations (1.2 X 10(8) particles/mouse), reached and optimum at 1.3 X 10(5) particles/mouse, and decreased with virus dilution.