3D printing of tablets using inkjet with UV photoinitiation
3D printing of tablets using inkjet with UV photoinitiation
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DOI：
10.1016/j.ijpharm.2017.06.085
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发表时间：
2017-08-30
影响因子：
5.8
通讯作者：
Wildman, Ricky D.
中科院分区：
文献类型：
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作者：
Clark, Elizabeth A.;Alexander, Morgan R.;Wildman, Ricky D.
增材制造（AM）在药物递送和药物/医疗器械制造领域提供了显著的潜在益处。在AM工艺中，3D喷墨打印能够精确沉积配方，同时作为制造平台提供了显著扩大或扩大规模的潜力。这项工作假设可以开发出合适的溶剂型油墨制剂，其允许生产满足药用片剂所需标准的固体剂型，同时提供灵活和个性化制造的平台。我们使用压电激活喷墨3D打印盐酸罗匹尼罗来证明这一点。生产的片剂由含有药物的交联聚（乙二醇二丙烯酸酯）（PEGDA）水凝胶基质组成，在低氧环境中使用Irgacure 2959水溶液进行光引发。在0.41 mg的盐酸罗匹尼罗载量下，药物从片剂中的释放显示为Fickian。拉曼和IR光谱表明高度交联和形成无定形固体分散体。这是UV喷墨3D打印片剂的首次出版物。因此，这项工作为将可扩展、高精度和定制的基于喷墨的增材制造转化为制药行业开辟了可能性。(C)2017由Elsevier B. V.出版
Additive manufacturing (AM) offers significant potential benefits in the field of drug delivery and pharmaceutical/medical device manufacture. Of AM processes, 3D inkjet printing enables precise deposition of a formulation, whilst offering the potential for significant scale up or scale out as a manufacturing platform. This work hypothesizes that suitable solvent based ink formulations can be developed that allow the production of solid dosage forms that meet the standards required for pharmaceutical tablets, whilst offering a platform for flexible and personalized manufacture. We demonstrate this using piezo-activated inkjetting to 3D print ropinirole hydrochloride. The tablets produced consist of a cross-linked poly(ethylene glycol diacrylate) (PEGDA) hydrogel matrix containing the drug, photoinitiated in a low oxygen environment using an aqueous solution of Irgacure 2959. At a Ropinirole HCl loading of 0.41 mg, drug release from the tablet is shown to be Fickian. Raman and IR spectroscopy indicate a high degree of cross-linking and formation of an amorphous solid dispersion. This is the first publication of a UV inkjet 3D printed tablet. Consequently, this work opens the possibility for the translation of scalable, high precision and bespoke ink-jet based additive manufacturing to the pharmaceutical sector. (C) 2017 Published by Elsevier B.V.