Effect of maternal PCOS and PCOS-like phenotype on the offspring's health.
Effect of maternal PCOS and PCOS-like phenotype on the offspring's health.
复制标题
DOI：
10.1016/j.mce.2015.11.030
复制
发表时间：
2016-11-05
影响因子：
4.1
通讯作者：
Padmanabhan V
中科院分区：
文献类型：
--
作者：
Puttabyatappa M;Cardoso RC;Padmanabhan V
多囊卵巢综合症（PCOS）是一种异质性内分泌疾病，其生殖和代谢异常都会影响育龄妇女。虽然多囊卵巢综合症的确切起源尚不清楚，但临床和动物研究的观察结果表明，母亲雄激素过多症可能是一个促成因素。由于患有 PCOS 的女性在怀孕期间表现出高雄激素血症，因此妊娠内分泌环境的变化可能在该综合征的垂直传播中发挥作用。这篇综述利用表现出 PCOS 样表型的动物模型的研究结果，讨论了 PCOS 的潜在发育起源、母亲 PCOS 对后代健康的影响以及产后环境的贡献。此外，这篇综述强调了人类妊娠早期数据的缺乏以及动物实验的重要性，以更好地了解成人疾病编程中涉及的细胞和分子机制，从而帮助确定预防和治疗策略的治疗靶点。
Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine disorder with both reproductive and metabolic abnormalities affecting women of reproductive age. While the exact origin of PCOS is unknown, observations from clinical and animal studies suggest that maternal hyperandrogenism may be a contributing factor. Because women with PCOS manifest hyperandrogenism during pregnancy, changes in the gestational endocrine milieu may play a role in the vertical transmission of this syndrome. This review discusses the potential developmental origins of PCOS, the impact of maternal PCOS on the offspring’s health and contributions of the postnatal environment, capitalizing on findings from animal models that exhibit a PCOS-like phenotype. In addition, this review highlights the scarcity of data at early gestational stages in humans and the importance of animal experimentation to better understand the cellular and molecular mechanisms involved in the programming of adult diseases, therefore, helping identify therapeutic targets for preventive and treatment strategies.