Fabrication of Pdop/Ag/Pdop Film on NiTi Alloys for Enhancing Their Corrosion Resistant and Antibacterial Properties
Fabrication of Pdop/Ag/Pdop Film on NiTi Alloys for Enhancing Their Corrosion Resistant and Antibacterial Properties
复制标题
NiTi合金上制备Pdop/Ag/Pdop薄膜以增强其耐腐蚀和抗菌性能
DOI：
10.1166/sam.2019.3705
复制
发表时间：
2019-12
影响因子：
0.9
通讯作者：
Jiehe Sui
中科院分区：
文献类型：
--
作者：
Yongkui Yin;Ying Li;Wei Cai;Jiehe Sui
NiTi合金因其独特的性能在生物医学领域得到了广泛的应用。然而，NiTi合金的高镍含量是其在生物医学领域应用的主要问题。此外，术后感染仍有可能发生
由于NiTi固有的不令人满意的抗菌活性。为了克服上述障碍，在NiTi表面覆盖银-聚多巴胺（Ag/Pdop）复合膜。改性后的NiTi比抛光后的NiTi具有更好的抗菌性和耐腐蚀性
但对人骨髓间充质干细胞（hBMSCs）有较高的细胞毒性。为了提高细胞相容性，在Ag/Pdop表面包覆第二层聚多巴胺（Pdop）膜，形成一种新型的三明治结构Pdop/Ag/Pdop复合膜。尽管Pdop/Ag/Pdop表现出较弱的抗菌性能
与Ag/Pdop相比，其细胞相容性明显增强。此外，Pdop/Ag/Pdop改性NiTi的耐蚀性优于Ag/Pdop改性NiTi。这些优异的性能使得Pdop/Ag/Pdop修饰的NiTi更适合于生物医学领域。
NiTi alloys have been intensively applied in biomedical fields because of their unique intrinsic properties. However, the high content of nickel of NiTi alloys is the major concern on their applications of biomedical fields. In addition, the postoperative infections still may be occurred
due to the intrinsic unsatisfied antibacterial activity of NiTi. To overcome the above barriers, a silver-polydopamine (Ag/Pdop) composite film was covered on NiTi surface. The modified NiTi exhibited much better antibacterial and corrosion resistance properties than that of the polished NiTi
but higher cell toxicity to human bone mesenchymal (hBMSCs). In order to improve the cytocompatibility, a second polydopamine (Pdop) film was coated on Ag/Pdop, forming a novel sandwich like Pdop/Ag/Pdop composite film. Despite the Pdop/Ag/Pdop exhibited a weaker antibacterial performance
than that of Ag/Pdop, its cytocompatibility enhanced obviously. In addition, the Pdop/Ag/Pdop modified NiTi showed a better corrosion resistance than that of the Ag/Pdop. The above excellent properties made the Pdop/Ag/Pdop modified NiTi more suitable for biomedical fields.