Proteolytic activation and solubilization of adenylate and guanylate cyclases
Proteolytic activation and solubilization of adenylate and guanylate cyclases
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腺苷酸和鸟苷酸环化酶的蛋白水解激活和溶解
DOI：
10.1016/0303-7207(83)90028-x
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发表时间：
1983
影响因子：
4.1
通讯作者：
M. Lacombe
中科院分区：
文献类型：
--
作者：
J. Hanoune;D. Stengel;M. Lacombe
It has long been established that proteolytic events are involved in the renewal of body proteins, thus contributing to the dynamic equilibrium of the organism at par with the biosynthetic processes. Proteolytic enzymes have also been extensively utilized for elucidating the structure of proteins and their interactions with surrounding elements, for example, the vectorial anatomy of membrane proteins. More recently, the role of proteolysis as a major control element in the initiation and regulation of physiological functions has emerged as a result of the discovery of the proteolytic transformation of inactive precursors into active enzymes by the selective enzymatic cleavage of peptide bonds. These events are steps of complex cascades of activation, or else they contribute to the processing or maturation of specific proteins, sometimes from a common precursor. The physiological role of proteolysis is now recognized beyond any doubt (for a short review see Neurath and Walsh, 1976).Over the past 20 years, cyclic nucleotides have occupied the centre stage in the field of biological regulatory effectors. Cyclic AMP is the intracellular mediator of a variety of hormonal effects and is a key intracellular regulator of a number of cellular processes in a variety of living cells. The synthesis of cyclic AMP is catalysed by the enzyme adenylate cyclase (EC 4.6.1.1). This enzyme is located, almost exclusively, in cell membranes and can be stimulated by membrane-active hormonal agents which promote the accumulation of cyclic AMP in the intact cell.
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鸟嘌呤核苷酸抑制 cyc-S49 小鼠淋巴瘤细胞膜腺苷酸环化酶。
DOI：
--
发表时间：
1982
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Hildebrandt,JD;Hanoune,J;Birnbaumer,L
通讯作者：
Birnbaumer,L
腺苷酸环化酶的调节成分。
DOI：
--
发表时间：
1981
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Hanski,E;Sternweis,PC;Northup,JK;Dromerick,AW;Gilman,AG
通讯作者：
Gilman,AG
腺苷酸环化酶调节成分的鸟嘌呤核苷酸激活位点。
DOI：
--
发表时间：
1982
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Northup,JK;Smigel,MD;Gilman,AG
通讯作者：
Gilman,AG
DOI：
--
发表时间：
1982
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Stiles,GL;Lefkowitz,RJ
通讯作者：
Lefkowitz,RJ
从视网膜杆外节中纯化和表征环 GMP 磷酸二酯酶的 γ 调节亚基。
DOI：
--
发表时间：
1982
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Hurley,JB;Stryer,L
通讯作者：
Stryer,L