Triphasic nanocolloids
Triphasic nanocolloids
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DOI：
10.1021/ja060836n
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发表时间：
2006-05-31
影响因子：
15
通讯作者：
Lahann, Joerg
中科院分区：
文献类型：
--
作者：
Roh, Kyung-Ho;Martin, David C.;Lahann, Joerg
三相纳米胶体，即具有三个不同隔室的纳米胶体，成功地通过使用通电共喷射制备。同时操纵具有层流的三种平行液体产生在喷射液体之间具有三个界面的液滴。在高电位下，从液滴三相点产生单一液体射流。在整个喷射过程中保持相之间的分离，并产生三相纳米胶体。使用聚（环氧乙烷）、聚（丙烯酸）和聚（丙烯酰胺-共-丙烯酸）溶液，并验证其与工艺相容。荧光标记的生物分子被选择性地掺入到纳米胶体的每个相中，并采用共聚焦激光扫描显微镜进行表征。扫描电子显微镜的结果证实，胶体的尺寸范围内的纳米胶体。这种制备多室纳米胶体的简单而通用的技术预计将对药物输送，分子成像和智能显示产生重大影响。
Triphasic nanocolloids, that is, nanocolloids with three distinct compartments, were successfully produced by use of electrified co-jetting. Simultaneous manipulation of the three parallel liquid with laminar flows yielded a liquid droplet with three interfaces between the jetting liquids. Under a high electric potential, a single liquid jet was produced from the triple point of the droplet. Separation between the phases was maintained throughout the jetting process and resulted in triphasic nanocolloids. Poly(ethylene oxide), poly(acrylic acid), and poly(acrylamide-co-acrylic acid) solutions were used and verified to be compatible with the process. Fluorescent-labeled biomolecules were selectively incorporated in each phase of the nanocolloids, and confocal laser scanning microscopy was employed for the characterization. Scanning electron microscopy results verified that the sizes of the colloids are in the range of nanocolloids. This simple and versatile technique to fabricate multicompartment nanocolloids is expected to have great impact on drug delivery, molecular imaging, and smart displays.