Epidemiologic characteristics and clinical course of patients with malignant eyelid tumors in an incidence cohort in Olmsted County, Minnesota
Epidemiologic characteristics and clinical course of patients with malignant eyelid tumors in an incidence cohort in Olmsted County, Minnesota
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DOI：
10.1016/s0161-6420(99)90161-6
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发表时间：
1999-04-01
期刊：
影响因子：
13.7
通讯作者：
Bartley, GB
中科院分区：
文献类型：
--
作者：
Cook, BE;Bartley, GB
目的：确定发病队列中恶性眼睑肿瘤患者的流行病学和临床特征。设计：队列系列。参与者：使用计算机检索系统识别居住在明尼苏达州奥姆斯特德县的所有患者，这些患者在 1976 年至 1990 年 15 年间新诊断出恶性眼睑肿瘤。对患者病历进行人口统计和临床数据审查。干预：冰冻切片手术切除组织病理学分析、莫氏显微切除、电干燥和刮宫是主要治疗方法。主要指标：无肿瘤存活。结果：发病队列包括 174 名患者，每人有 1 个肿瘤；男性和女性同样受到影响，而且所有患者都是白人。肿瘤最常见于下眼睑（n = 85；48.9%）和内眦区域（n = 48；27.6%），但左右两侧的发病率相同。在174个肿瘤中，158个是基底细胞癌（90.8％），15个是鳞状细胞癌（8.6％），1个（0.6％）是恶性黑色素瘤。经年龄和性别调整后，基底细胞癌、鳞状细胞癌和恶性黑色素瘤的发病率分别为每年每10万人中14.35、1.37和0.08。没有发现皮脂腺癌病例。所有眼睑肿瘤的 5 年和 10 年复发率分别为 2% 和 3%。身体其他部位发生不相关恶性肿瘤的概率在 5 年时约为 9%，在 10 年时约为 15%。结论：基底细胞癌是白人中最常见的恶性眼睑肿瘤。下眼睑和内眦是最常见的起源部位。男性和女性同样受到影响。手术切除后复发并不常见。
Objective: To determine the epidemiologic and clinical characteristics of patients with malignant eyelid tumors in an incidence cohort.Design: Cohort series.Participants: A computerized retrieval system was used to identify all patients residing in Olmsted County, Minnesota, who had a newly diagnosed malignant eyelid tumor during the 15-year interval from 1976 through 1990. The patients' medical records were reviewed for demographic and clinical data.Intervention: Surgical excision with frozen-section histopathologic analysis, Mohs' micrographic excision, and electrodesiccation and curettage were the primary methods of treatment.Main Outcome Measures: Survivorship free of tumor.Results: The incidence cohort included 174 patients who each had 1 tumor; men and women were equally affected, and all patients were white. Tumors developed most commonly on the lower eyelid (n = 85; 48.9%) and in the medial canthal region (n = 48; 27.6%) but involved the right and left sides with equal frequency. Of the 174 tumors, 158 were basal cell carcinomas (90.8%), 15 were squamous cell carcinomas (8.6%), and 1 (0.6%) was a malignant melanoma. The age- and gender-adjusted incidence rates for basal cell carcinoma, squamous cell carcinoma, and malignant melanoma were 14.35, 1.37, and 0.08 per 100,000 individuals per year, respectively. No cases of sebaceous gland carcinoma were identified. The 5- and 10-year recurrence rates for all tumors on the eyelid were 2% and 3%, respectively. The probability of an unrelated malignancy developing elsewhere in the body was approximately 9% at 5 years and 15% at In years.Conclusions: Basal cell carcinoma is the most common malignant eyelid tumor in whites. The lower eyelid and medial canthus are the most frequent sites of origin. Men and women are equally affected. Recurrence after surgical excision is uncommon.