Evolution of Medical Approaches and Prominent Therapies in Breast Cancer.
Evolution of Medical Approaches and Prominent Therapies in Breast Cancer.
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DOI：
10.3390/cancers14102450
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发表时间：
2022-05-16
期刊：
影响因子：
5.2
通讯作者：
Buxton, Iain L. O.
中科院分区：
文献类型：
--
作者：
Duan, Suzann;Buxton, Iain L. O.
乳腺癌是全球女性发病和死亡的主要原因，死亡率在很大程度上是由转移性疾病导致的。尽管人们齐心协力去揭示并针对这些情况背后的机制，但转移性乳腺癌的五年相对生存率仍然极低，仅为27%。为了更好地为这种疾病的未来治疗方向提供信息，审视癌症研究从基础概念到治疗方法及其缺陷的演变是有帮助的。这篇综述旨在提供从古代到现代乳腺癌治疗历史的丰富概述，并以免疫疗法的快速发展以及我们最终迈向个性化医疗作为结尾。
对乳腺癌医疗方法起源的考察表明，这种疾病是最难治疗的疾病之一。随着乳腺癌的早期识别、诊断和治疗的发展，我们将进入这样一个时代：每个患者及其癌症都能得到评估，以确定针对患者个体的独特（个性化）治疗方法。人类尝试治疗乳腺癌已有数千年的历史。即使在今天，这种疾病每年仍夺走数千人的生命。鉴于对癌症诊断和治疗的理解日益复杂，以及我们在最困难的病例中最终未能提供治愈方法，反思我们理解的起源是有指导意义的。
Breast cancer is a leading cause of morbidity and mortality in women worldwide, with mortality rates largely driven by metastatic disease. Despite concerted efforts to uncover and target the mechanisms underlying these events, the five-year relative survival rate for metastatic breast cancer remains an abysmal 27%. To better inform future directions for managing this disease, it is helpful to examine the evolution of cancer research, from foundational concepts to therapies and their pitfalls. This review aims to provide a rich overview of the history of breast cancer therapies spanning antiquity to the modern era, concluding with the rapid advancements in immunotherapies and our eventual progression towards personalized medicine. An examination of the origins of medical approaches to breast cancer marks this disease as one of the most difficult to manage. As the early identification, diagnosis and treatment of breast cancer evolve, we will move to a time when each patient and their cancer can be assessed to determine unique patient-specific (personalized) approaches to therapy. Humans have attempted to manage breast cancer for millennia. Even today, the disease claims thousands of lives each year. In light of the increasingly sophisticated understanding of cancer diagnosis and treatment, together with our ultimate failure to offer a cure in the most difficult cases, it is instructive to reflect on the beginnings of our understanding.
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影响因子：
168.9
作者：
Davies, Christina;Pan, Hongchao;Godwin, Jon;Gray, Richard;Arriagada, Rodrigo;Raina, Vinod;Abraham, Mirta;Medeiros Alencar, Victor Hugo;Badran, Atef;Bonfill, Xavier;Bradbury, Joan;Clarke, Michael;Collins, Rory;Davis, Susan R.;Delmestri, Antonella;Forbes, John F.;Haddad, Peiman;Hou, Ming-Feng;Inbar, Moshe;Khaled, Hussein;Kielanowska, Joanna;Kwan, Wing-Hong;Mathew, Beela S.;Mittra, Indraneel;Mueller, Bettina;Nicolucci, Antonio;Peralta, Octavio;Pernas, Fany;Petruzelka, Lubos;Pienkowski, Tadeusz;Radhika, Ramachandran;Rajan, Balakrishnan;Rubach, Maryna T.;Tort, Sera;Urrutia, Gerard;Valentini, Miriam;Wang, Yaochen;Peto, Richard
通讯作者：
Peto, Richard
影响因子：
7.3
作者：
Decker WK;da Silva RF;Sanabria MH;Angelo LS;Guimarães F;Burt BM;Kheradmand F;Paust S
通讯作者：
Paust S
影响因子：
51.1
作者：
Denkert, Carsten;von Minckwitz, Gunter;Loibl, Sibylle
通讯作者：
Loibl, Sibylle
影响因子：
32.4
作者：
Butte, Manish J.;Keir, Mary E.;Freeman, Gordon J.
通讯作者：
Freeman, Gordon J.
DOI：
10.1073/pnas.89.10.4285
发表时间：
1992-05-15
影响因子：
11.1
作者：
CARTER, P;PRESTA, L;SHEPARD, HM
通讯作者：
SHEPARD, HM