The impact of euglycemia and hyperglycemia on stimulated pituitary hormone release in insulin-dependent diabetics.
The impact of euglycemia and hyperglycemia on stimulated pituitary hormone release in insulin-dependent diabetics.
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正常血糖和高血糖对胰岛素依赖型糖尿病患者刺激垂体激素释放的影响。
DOI：
10.1210/jcem-52-6-1230
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
W. Waldhäusl
中科院分区：
文献类型：
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作者：
H. Vierhapper;B. Grubeck‐Loebenstein;P. Bratusch;S. Panzer;W. Waldhäusl
为探讨不同血糖浓度对垂体激素释放的影响，对6例男性胰岛素依赖型糖尿病患者同时静脉注射LRH（200 μ g）、TRH（400 μ g）和精氨酸（30 μ g/30 min），测定血清LH、FSH、TSH、PRL和GH浓度。通过反馈控制和自动葡萄糖控制胰岛素输注系统将BG浓度钳制在正常血糖（BG 4-5 mmol/L）或高血糖（BG，14-18 mmol/L）水平。在正常血糖和高血糖稳态下，血清LH、FSH、TSH和PRL浓度的增加相似，而在高血糖钳夹期间，GH对精氨酸的反应受到抑制（P <0.01）。在高血糖症期间，外源性胰岛素的省略并没有改变所观察到的激素反应。因此，在垂体水平对足够的急性刺激作出反应时，LH、FSH、TSH和PRL的释放不受胰岛素依赖型糖尿病高血糖的调节，而精氨酸诱导的GH释放受到抑制。由于精氨酸对GH的影响最有可能是通过对下丘脑的作用介导的，因此数据表明，葡萄糖浓度升高可能对下丘脑而不是垂体水平的GH分泌产生调节影响。
To study the influence of different blood glucose (BG) concentrations on the release of pituitary hormones, the effect of the simultaneous iv administration of LRH (200 micrograms), TRH (400 micrograms), and arginine (30 g/30 min) upon the serum concentrations of LH, FSH, TSH, PRL, and GH was determined in six male insulin-dependent diabetics. BG concentration was clamped by feedback control and an automated glucose-controlled insulin infusion system at euglycemic (BG 4-5 mmol/liter) or hyperglycemic (BG, 14-18 mmol/liter) levels. Increments in serum concentrations of LH, FSH, TSH, and PRL were similar in the euglycemic and hyperglycemic steady states, whereas the GH response to arginine was suppressed during the hyperglycemic clamp (P less than 0.01). Omission of exogenous insulin during hyperglycemia did not modify the observed hormonal responses. Thus, the release of LH, FSH, TSH, and PRL in response to adequate acute stimuli at the pituitary level is not modulated by hyperglycemia in insulin-dependent diabetes, while arginine-induced GH release is suppressed. Since the effect of arginine on GH is most likely mediated by an action on the hypothalamus, the data suggest that elevated glucose concentrations may exert their modulatory influence on GH secretion at the hypothalamic rather than at the pituitary level.