Morphological phase diagram for lipid membrane domains with entropic tension.
Morphological phase diagram for lipid membrane domains with entropic tension.
复制标题
具有熵张力的脂质膜域的形态相图。
DOI：
10.1103/physrevlett.106.057801
复制
发表时间：
2011
影响因子：
8.6
通讯作者：
Klug,WS
中科院分区：
文献类型：
--
作者：
Rim,JE;Ursell,TS;Phillips,R;Klug,WS
具有对称小叶组成的相分离脂质囊泡中的圆形结构域通常表现出三种稳定的形态：平坦的、微凹的和出芽的。然而，稳定的凹坑（即，部分出芽域）提出了一个难题，因为简单的弹性域形状理论预测，在没有自发曲率的情况下，只有扁平和球形出芽域是机械稳定的。我们认为，这种不一致性产生的失败的恒定的表面张力合奏适当占熵弯曲波动的影响。制定膜弹性内的熵张力合奏，其中张力表示从膜的热弯曲提取膜面积的自由能成本，我们计算的形态相图，包含区域的机械稳定性的每个平面，酒窝，和出芽域形态。
Circular domains in phase-separated lipid vesicles with symmetric leaflet composition commonly exhibit three stable morphologies: flat, dimpled, and budded. However, stable dimples (i.e., partially budded domains) present a puzzle since simple elastic theories of domain shape predict that only flat and spherical budded domains are mechanically stable in the absence of spontaneous curvature. We argue that this inconsistency arises from the failure of the constant surface tension ensemble to properly account for the effect of entropic bending fluctuations. Formulating membrane elasticity within an entropic tension ensemble, wherein tension represents the free energy cost of extracting membrane area from thermal bending of the membrane, we calculate a morphological phase diagram that contains regions of mechanical stability for each of the flat, dimpled, and budded domain morphologies.
扩展脂质双层的定义：弹性在蛋白质和脂质组织中的作用
影响因子：
3.3
作者：
T. Ursell
通讯作者：
T. Ursell