Results from the Workshop "Problem Formulation for the Use of Gene Drive in Mosquitoes".
Results from the Workshop "Problem Formulation for the Use of Gene Drive in Mosquitoes".
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DOI：
10.4269/ajtmh.16-0726
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发表时间：
2017-03
期刊：
影响因子：
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通讯作者：
James S
中科院分区：
文献类型：
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作者：
Roberts A;Andrade PP;Okumu F;Quemada H;Savadogo M;Singh JA;James S
近一个世纪以来，减少疟疾发病率一直是公共卫生的优先事项。新技术和相关的病媒控制战略在持续减少的前景中发挥着重要作用。CRISPR/Cas9基因编辑系统的发展为利用基因驱动构建体减少或改变病媒种群以降低疟疾发病率创造了新的可能性。然而，在开发和利用这些技术之前，有必要了解和评估对人类或环境造成任何潜在危害的可能性。为了启动这一进程，美国国立卫生研究院基金会和国际生命科学研究所研究基金会组织了一次专家讲习班，审议在非洲利用冈比亚按蚊基因驱动控制疟疾的潜在风险。由此产生的讨论产生了一系列的共识点，在此报告。
Reducing the incidence of malaria has been a public health priority for nearly a century. New technologies and associated vector control strategies play an important role in the prospect of sustained reductions. The development of the CRISPR/Cas9 gene editing system has generated new possibilities for the use of gene-drive constructs to reduce or alter vector populations to reduce malaria incidence. However, before these technologies can be developed and exploited, it will be necessary to understand and assess the likelihood of any potential harms to humans or the environment. To begin this process, the Foundation for the National Institutes of Health and the International Life Sciences Institute Research Foundation organized an expert workshop to consider the potential risks related to the use of gene drives in Anopheles gambiae for malaria control in Africa. The resulting discussion yielded a series of consensus points that are reported here.