Reduced expression of P120 catenin in cholangiocarcinoma correlated with tumor clinicopathologic parameters
Reduced expression of P120 catenin in cholangiocarcinoma correlated with tumor clinicopathologic parameters
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DOI：
10.3748/wjg.14.3739
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发表时间：
2008-06-21
影响因子：
4.3
通讯作者：
Wang, Hong-Yang
中科院分区：
文献类型：
--
作者：
Zhai, Bo;Yan, He-Xin;Wang, Hong-Yang
目的：探讨肝内胆管癌（ICC）中P120的表达与临床病理参数的关系。方法：采用Dako Envision试剂盒对42例ICC标本进行E-cadherin和P120 catenin的免疫组化研究。结果：E-cadherin和P120表达降低27例（64.3%）和31例(73.8%)。 E-cadherin和P120表达均与肿瘤组织学分级（chi（2）= 9.333，P = 009和chi（2）= 11.71，P = 0.003），TNM分期（chi（2）= 8.627，P = 0.035和chi（2）= 13.123，P = 0.004），肝内显着相关转移（分别为 chi(2) = 7.292，P = 0.007 和 chi(2) = 4.657，P = 0.041）和患者生存（分别为 chi(2) = 6.351，P = 0.002 和 chi(2) = 4.023，P = 0.000）。此外，P120的表达与E-cadherin的表达一致(chi(2)=13.797，P=0.000)，表明P120的表达可能依赖于E-cadherin的表达。最后，在Cox回归模型中发现只有P120表达是独立的预后因素（r = 0.088，P = 0.049）。结论：E-cadherin和P120表达下调在ICC中频繁发生，并有助于肿瘤的进展和发展。两者都可能是预测肿瘤侵袭、转移和患者生存的有价值的生物标志物，但只有P120是ICC的独立预后因素。 (C) 2008 年 WJG 出版社。版权所有。
AIM: To investigate the relationship between the expression of P120 and the clinicopathologic parameters in intrahepatic cholangiocarcinoma (ICC).METHODS: An immunohistochemical study of E-cadherin and P120 catenin was performed on 42 specimens of ICC with a Dako Envision kit.RESULTS: The expression of E-cadherin and P120 was reduced in 27 cases (64.3%) and 31 cases (73.8%), respectively. Both E-cadherin and P120 expressions were significantly correlated with the tumor histological grade (chi(2) = 9.333, P = 009 and chi(2) = 11.71, P = 0.003), TNM stage (chi(2)= 8.627, P = 0.035 and chi(2) = 13.123, P = 0.004), intrahepatic metastasis (chi(2) = 7.292, P 0.007 and chi(2) = 4.657, P = 0.041, respectively) and patients' survival (chi(2) = 6.351, P = 0.002 and chi(2) = 4.023, P = 0.000, respectively). In addition, the expression of P120 was in concordance with that of E-cadherin (chi(2) = 13.797, P = 0.000), indicating that the expression of P120 may be dependent on that of E-cadherin. Finally, only P120 expression was found to be an independent prognostic factor in Cox regression model (r = 0.088, P = 0.049).CONCLUSION: Down-regulated expression of E-cadherin and P120 occurs frequently in ICC and contributes to the progression and development of tumor. Both of them may be valuable biologic markers for predicting tumor invasion, metastasis and patients' survival, but only P120 is an independent prognostic factor for ICC. (C) 2008 The WJG Press. All rights reserved.