Vasoactive intestinal peptide and neuropeptide modulation of the immune response.
Vasoactive intestinal peptide and neuropeptide modulation of the immune response.
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DOI：
10.4049/jimmunol.135.2.792
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发表时间：
1985-08
影响因子：
4.4
通讯作者：
M. O'dorisio;C. Wood;T. O'dorisio
中科院分区：
文献类型：
--
作者：
M. O'dorisio;C. Wood;T. O'dorisio
证据正在迅速积累，以支持神经免疫轴的存在。然而，单个神经递质在调节免疫功能中的确切作用仍有待阐明。本文重点介绍血管活性肠肽（VIP）在调节淋巴细胞功能中的作用。我们研究其作为神经递质的地位，包括神经元和可能的神经元合成位点的证据。此外，我们目前的数据来证明VIP受体在人类淋巴细胞的存在，并使用Molt 4b成淋巴细胞系作为模型，显示VIP介导的腺苷酸环化酶的激活导致cAMP依赖性蛋白激酶介导的特定Molt蛋白的磷酸化。最后，我们讨论了VIP受体对淋巴细胞的功能意义，并提出了一个模型，神经肽诱导的炎症与可能的治疗应用，这令人兴奋的新领域的神经免疫学。
Evidence is rapidly accumulating to support the existence of a neuroimmune axis. However, the precise role of individual neurotransmitters in regulating immune function remains to be elucidated. In this review we focus on the role of vasoactive intestinal peptide (VIP) in modulation of lymphocyte function. We examine its status as a neurotransmitter, including evidence for neuronal and possible extraneuronal sites of synthesis. Further, we present data to demonstrate the presence of VIP receptors in human lymphocytes and, using the Molt 4b lymphoblastic cell line as a model, show VIP-mediated activation of adenylate cyclase leading to cAMP-dependent protein kinase-mediated phosphorylation of a specific Molt protein. Finally, we discuss the functional significance of VIP receptors on lymphocytes and present a model of neuropeptide-induced inflammation with possible therapeutic applications of this exciting new field of neuroimmunology.