N-acetyltransferase 2 Polymorphisms and Risk of Esophageal Cancer in a Chinese Population
N-acetyltransferase 2 Polymorphisms and Risk of Esophageal Cancer in a Chinese Population
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N-乙酰转移酶2多态性与中国人群食管癌风险
DOI：
10.1371/journal.pone.0087783
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发表时间：
2014-02-19
期刊：
影响因子：
3.7
通讯作者：
Gu, Haiyong
中科院分区：
文献类型：
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作者：
Wang, Liming;Tang, Weifeng;Gu, Haiyong
食管癌是2009年中国第五大常见癌症，也是第四大癌症相关死亡原因。遗传因素可能在食管鳞状细胞癌（ESCC）的发生过程中起重要作用。我们进行了一项基于医院的病例对照研究，以评估10个NAT2标记单核苷酸多态性（snp）对ESCC风险的影响。629例ESCC病例和686例对照。采用结扎检测反应法测定其基因型。在单位点分析中，病例与对照组NAT2 rs1565684 T b> C SNP基因型频率差异有统计学意义（p = 0.057）。NAT2 rs1565684 CC基因型与ESCC的临界风险显著增加相关（CC与TT：校正OR = 1.77, 95% CI = 0.97-3.21, p = 0.063； CC与TT/TC：校正OR = 1.68, 95% CI = 0.93-3.04, p = 0.085）。这种关联在老年患者和从不饮酒的患者中尤为明显。经Bonferroni校正后，在所有比较模型中，NAT2 rs1565684 tb> C SNP与ESCC风险无相关性（p b> 0.05）。对于其他9个NAT2 snp，经Bonferroni校正后，在所有比较模型中，9个snp也与ESCC风险无关（p < 0.05）。因此，9个NAT2标记snp与ESCC风险无关。NAT2 rs1565684 tb> C SNP可能在ESCC病因学中起轻微作用。另外，需要更大规模的研究和组织特异性生物学特性来证实目前的发现。
Esophageal cancer was the fifth most commonly diagnosed cancer and the fourth leading cause of cancer-related death in China in 2009. Genetic factors might play an important role in the carcinogenesis of esophageal squamous cell carcinoma (ESCC). We conducted a hospital-based case-control study to evaluate ten NAT2 tagging single nucleotide polymorphisms (SNPs) on the risk of ESCC. Six hundred and twenty-nine ESCC cases and 686 controls were recruited. Their genotypes were determined using the ligation detection reaction method. In the single locus analyses, there was a borderline statistically significant difference in genotype frequencies of NAT2 rs1565684 T>C SNP between the cases and the controls (p = 0.057). The NAT2 rs1565684 CC genotype was associated with a borderline significantly increased risk for ESCC (CC vs. TT: adjusted OR = 1.77, 95% CI = 0.97–3.21, p = 0.063 and CC vs. TT/TC: adjusted OR = 1.68, 95% CI = 0.93–3.04, p = 0.085). The association was evident among older patients and patients who never drunk. After the Bonferroni correction, in all comparison models, NAT2 rs1565684 T>C SNP was not associated with ESCC risk (p>0.05). For the other nine NAT2 SNPs, after Bonferroni correction, in all comparison models, the nine SNPs were also not associated with ESCC risk (p>0.05). Thus, nine NAT2 tagging SNPs were not associated with risk of ESCC. NAT2 rs1565684 T>C SNP might play a slight role in ESCC etiology. Additional, larger studies and tissue-specific biological characterization are required to confirm the current findings.