ODR-1 acts in AWB neurons to determine the sexual identity of C. elegans pheromone blends.
ODR-1 acts in AWB neurons to determine the sexual identity of C. elegans pheromone blends.
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DOI：
10.17912/micropub.biology.000507
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发表时间：
2022
影响因子：
--
通讯作者：
Ruvinsky I
中科院分区：
文献类型：
--
作者：
Aprison EZ;Ruvinsky I
动物信息素混合物的效价可因单个成分相对丰度的差异而变化。例如，在秀丽隐杆线虫中，一种信息素混合物被认为是“雄性”还是“雌雄同体”是由ascr#10和ascr#3的浓度比决定的。评估这一比率的神经元机制目前尚不清楚。我们提供的数据表明，AWB神经元中guanyyl环化酶ODR-1的功能是ascr#3抵消ascr#10活性的作用所必需的。这一发现在神经机制中定义了一个新的模块，决定秀丽隐杆线虫信息素的性别身份。
Valence of animal pheromone blends can vary due to differences in relative abundance of individual components. For example, in C. elegans, whether a pheromone blend is perceived as “male” or “hermaphrodite” is determined by the ratio of concentrations of ascr#10 and ascr#3. The neuronal mechanisms that evaluate this ratio are not currently understood. We present data that suggest that the function of guanylyl cyclase ODR-1 in AWB neurons is required for the effect of ascr#3 that counteracts the activity of ascr#10. This finding defines a new module in the neuronal mechanism that determines the sexual identity of C. elegans pheromone.