SERPINE2/PN-1 regulates the DNA damage response and radioresistance by activating ATM in lung cancer
SERPINE2/PN-1 regulates the DNA damage response and radioresistance by activating ATM in lung cancer
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SERPINE2/PN-1通过激活ATM调节肺癌中的DNA损伤反应和放射抗性
DOI：
10.1016/j.canlet.2021.10.001
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发表时间：
2022
期刊：
影响因子：
9.7
通讯作者：
Shirong Zhang
中科院分区：
文献类型：
--
作者：
Jingjing Zhang;Qiong Wu;Lucheng Zhu;Shujun Xie;Linglan Tu;Yuhong Yang;Kan Wu;Yanyan Zhao;Yuqing Wang;Yasi Xu;Xueqin Chen;Shenglin Ma;Shirong Zhang
SERPINE 2基因敲低可通过介导RAD 51抑制肺癌的放射抗性和DNA损伤修复; SERPINE 2可通过与ATM直接相互作用促进ATM磷酸化; SERPINE 2 shRNA可减少IR诱导的G2/M期阻滞，并抑制体外迁移和侵袭; SERPINE 2高表达与肺腺癌预后不良相关。
HighlightsSERPINE2 knockdown inhibits radioresistance and DNA damage repair by mediating RAD51 in lung cancer.SERPINE2 promotes ATM phosphorylation by directly interacting with ATM in HR-mediated DNA repair.SERPINE2 shRNA reduces IR-induced G2/M arrest, and inhibits migration and invasion in vitro.High SERPINE2 expression is correlated with a poor prognosis in lung adenocarcinomas.