Management of non-genital herpes simplex virus infections in immunocompetent patients.
Management of non-genital herpes simplex virus infections in immunocompetent patients.
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免疫功能正常患者非生殖器单纯疱疹病毒感染的治疗。
DOI：
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发表时间：
1988
期刊：
影响因子：
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通讯作者：
Leigh Im
中科院分区：
文献类型：
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作者：
Leigh Im
：免疫功能正常的宿主中的非生殖器单纯疱疹病毒可引起多种原发感染——龈口炎、角结膜炎、疱疹性瘭疮和脑脊髓炎。口唇线虫的复发性感染非常常见，但通常是轻微的且具有自限性。单纯疱疹病毒感染的皮肤并发症包括疱疹性湿疹和多形红斑。阿昔洛韦全身治疗适用于脑脊髓炎、进行性疱疹性湿疹和常见的严重多形红斑。慢性、抑制性阿昔洛韦治疗可能有助于治疗严重的复发性感染或并发多形红斑/播散性感染。许多原发性和复发性感染可以通过简单的局部治疗来控制继发感染。没有证据表明全身治疗会影响停止治疗后的病毒潜伏期或复发感染。
: Non-genital herpes simplex virus in immunocompetent hosts causes a variety of primary infections--gingivostomatitis, keratoconjunctivitis, herpetic whitlow, and encephalomyelitis. Recurrent infections with orolabialis are very common, but are usually mild and self-limiting. Cutaneous complications of herpes simplex virus infections include eczema herpeticum and erytherma multiforme. Systemic treatment with acyclovir is indicated in encephalomyelitis, progressive eczema herpeticum, and frequent severe erythema multiforme. Chronic, suppressive acyclovir treatment may be helpful in severe recurrent infections or those complicated by erythema multiforme/dissemination. Many primary and recurrent infections can be treated with simple topical therapy to control secondary infection. There is no evidence that systemic treatment affects viral latency or recurrent infections following discontinuation of treatment.