Suitability of the cingulate cortex for neural control.
Suitability of the cingulate cortex for neural control.
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扣带皮层对神经控制的适用性。
DOI：
10.1109/tnsre.2006.886730
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发表时间：
2006
期刊：
影响因子：
--
通讯作者：
Kipke,DarylR
中科院分区：
文献类型：
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作者：
Marzullo,TimothyC;Miller,CharlesR;Kipke,DarylR
最近的神经假体工作主要集中在运动皮层作为自愿控制信号的来源。然而，运动皮层可能在上运动神经元退行性疾病（例如原发性侧索硬化症和肌萎缩性侧索硬化症）中受损。前额叶区域也有可能用于神经假体装置。在这里，我们报告了扣带皮层在神经修复模型中的使用。七只老鼠能够显着调节扣带皮层的尖峰活动以获得奖励。此外，单个神经元的实验提供了证据，表明扣带皮层神经元调节具有高度灵活性，因此可用于神经假体装置
Recent neuroprosthetic work has focused on the motor cortex as a source of voluntary control signals. However, the motor cortex can be damaged in upper motor neuron degenerative diseases such as primary lateral sclerosis and amyotrophic lateral sclerosis. The possibility exists that prefrontal areas may also be used in neuroprosthetic devices. Here, we report the use of the cingulate cortex in a neuroprosthetic model. Seven rats were able to significantly modulate spiking activity in the cingulate cortex in order to receive reward. Furthermore, experiments with single neurons provide evidence that the cingulate cortex neuronal modulation is highly flexible and thus useful for a neuroprosthetic device