Aldehyde- and Ketone-Induced Tandem Decarboxylation-Coupling (Csp3-Csp) of Natural α-Amino Acids and Alkynes
Aldehyde- and Ketone-Induced Tandem Decarboxylation-Coupling (Csp3-Csp) of Natural α-Amino Acids and Alkynes
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DOI：
10.1021/jo902319h
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发表时间：
2010-02-05
影响因子：
3.6
通讯作者：
Li, Chao-Jun
中科院分区：
文献类型：
--
作者：
Bi, Hai-Peng;Teng, Qingfeng;Li, Chao-Jun
以天然α-氨基酸为原料，在中性条件下，铜催化醛酮诱导的分子间串联脱羧偶联反应（Csp（3）-Csp），副产物仅为CO2和H2O.通过该方法得到了各种功能化的含氮化合物。在这些过程中，有趣的区域选择性的烷基化，这已合理化的相对稳定性的基础上提出的共振结构的计算方法。
An interesting aldehyde- and ketone-induced intermolecular tandem decarboxylation-coupling (Csp(3)-Csp) catalyzed by copper with use of natural alpha-amino acids as starting materials is developed under neutral conditions with the production of CO2 and H2O as the only by products. Various functionalized nitrogen-containing compounds were obtained by this method. In these processes, interesting regioselectivites of the alkylation were observed, which has been rationalized by the relative stability of proposed resonance structures based on computation methods.