Dogs, cats, and asthma: Will we ever really know the true risks and benefits?
Dogs, cats, and asthma: Will we ever really know the true risks and benefits?
复制标题
狗、猫和哮喘：我们真的能知道真正的风险和好处吗？
DOI：
10.1016/j.jaci.2016.08.021
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Johnson,ChristineCole
中科院分区：
文献类型：
--
作者：
Ownby,DennisR;Johnson,ChristineCole
在我们医学生涯的早期，我们中的许多人都被告知过敏“导致”哮喘。然而，我们可能也听说过，通常是从肺病学家那里，没有科学证据证明过敏和哮喘之间存在因果关系。经过多年的研究，为什么过敏和哮喘之间的关系仍然存在争议？1理解过敏性致敏与哮喘关系的一个重要挑战是我们对许多变量之间复杂相互作用的理解，这些变量最终导致肺的异常反应。肺高反应性似乎是最后的共同途径负责的各种症状，我们聚集在一起诊断哮喘。为了理解导致肺功能亢进的不同病理生理过程，人们提出了哮喘表型或内在型的概念。2在公认的表型中，过敏性哮喘似乎是最常见的。3过敏性哮喘通常定义为哮喘症状与暴露于空气中的过敏原之间的相关性，当可以证明对同一过敏原具有特异性的IgE抗体时。
Early in our medical careers many of us were told that allergies “cause” asthma. However, we probably also heard, usually from a pulmonologist, that there was no scientific evidence demonstrating a causal link between allergies and asthma. After years of study, why is the relationship between allergies and asthma still debated? 1An important challenge in understanding the relationship of allergic sensitization to asthma is our broadening understanding of the complex interactions among many variables which, ultimately lead to an abnormally responsive lung. Lung hyperresposiveness appears to be the final common pathway responsible for the various symptoms we cluster together for a diagnosis of asthma. Efforts to understand the different pathophysiologic processes responsible for pulmonary hyperactivity have led to the concept of asthma phenotypes or underlying endotypes. 2 Among the recognized phenotypes, allergic asthma appears to be the most common. 3 Allergic asthma is typically defined by an observed association between asthma symptoms and exposure to an airborne allergen when IgE antibodies specific for the same allergen can be demonstrated.