Journal of the American College of Cardiology: Clinical Electrophysiology: The Next Phase of the Voyage.
Journal of the American College of Cardiology: Clinical Electrophysiology: The Next Phase of the Voyage.
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美国心脏病学会杂志：临床电生理学：下一阶段的旅程。
DOI：
10.1016/j.jacep.2020.06.002
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发表时间：
2020
期刊：
影响因子：
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通讯作者：
Shivkumar,Kalyanam
中科院分区：
文献类型：
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作者：
Shivkumar,Kalyanam
2015年3月成为美国心脏病学会期刊家族的第五名成员。在短短5年的时间里，《JACC：临床电生理学》取得了显著的发展，现已成为该领域的知名期刊。创始编辑David Wilber博士和他的团队孜孜不倦地建立了基金会，并将这一JACC期刊家族的重要成员交给了现任编辑团队。结合我们对激发临床创新、临床研究和心脏电生理学（EP）临床实践的基础科学的热情，我们热切地踏上了下一阶段的航程。心脏电生理学在心脏病学的各个领域中是独一无二的，是一个“年轻”的领域，事实上，许多创建这一专业的有影响力的人仍然活跃在临床护理和教学中。在短短30年的时间里，一个主要是诊断专业，除了药物测试和少量外科手术之外几乎没有其他治疗方法的领域，已经转变为一个充满活力的介入专业。复杂的程序在心脏电位实验室现在是常规评估和治疗，即使是最具挑战性的心律失常。近年来，心律失常和心脏病的治疗方法受到神经科学、炎症生物学、生物工程以及计算和/或数据科学进展的有力影响。心脏EP最令人兴奋的特点是，临床实践提供了一个“检验”假设和自己辨别事实的机会，而不必从表面上接受当前的教条。通过测试来识别心律失常的机制是“生理学”在世界各地的EP实验室中每天都在发挥作用的一个很好的例子。这也是为什么任何新概念的颁布都可以被测试和证实的原因，并且延伸所有的谬论在心脏EP的世界里确实是非常短暂的！由于这个原因，机械研究将永远是该杂志的一个特色。所有生物医学科学的永久载体都指向临床护理，因此基础科学、转化科学、临床科学和人口科学对我们的读者和我们的团队都感兴趣，我们的目标是使这些内容易于访问和有意义。心脏EP领域所建立的基础科学是迷人的，揭示的，值得强调的，因为所有当前的治疗都可以追溯到基础发现。心脏冲动的形成始于34亿年前，当时离子通量需要膜蛋白，随后离子通道进化以支持年轻地球上的生命。最终，大自然完善了这个工具包，以确保适应陆地上的生活，进化出我们哺乳动物祖先心脏的窦性节律（大约1.6亿年前）。在细胞和器官水平上，心脏的肌肉细胞（心脏中只有三分之一的细胞是肌细胞）以同步的方式被激活，以产生兴奋-收缩耦合的生物学奇迹。的确，在人的80年寿命中，心脏忠实地跳动了大约30亿次。肌细胞是
March 2015 as the fifth member of the Journal of the American College of Cardiology family of journals. In a short span of 5 years, the JACC: Clinical Electrophysiology has seen remarkable growth and is now an established journal in the field. The founding editor Dr. David Wilber and his team worked tirelessly to establish the foundations and have handed this valued member of the JACC family of journals to the current editorial team. We eagerly embark on this next stage of the voyage, combining our enthusiasm for basic science that inspires clinical innovations, clinical research, and the clinical practice of cardiac electrophysiology (EP). Cardiac electrophysiology, unique among various fields of cardiology, is a “young” field and indeed many of the influential people who created this specialty are still active in clinical care and teaching. In a short span of 3 decades, a field that was predominantly a diagnostic specialty, with few therapies other than drug testing and a small number of surgical procedures, has been transformed into a dynamic interventional specialty. Sophisticated procedures in the cardiac EP lab are now routinely evaluating and treating even the most challenging arrhythmias. In recent years, therapeutic approaches for arrhythmias and heart disease have been powerfully influenced by advances in neurosciences, inflammation biology, bioengineering, and computational and/or data sciences.The most exciting feature of cardiac EP is the fact that clinical practice provides an opportunity to “test” hypotheses and discern facts for oneself, without having to take current dogmas at face value. Identifying mechanisms of arrhythmias by testing is a great example of “physiology” in action in EP labs across the world on a daily basis. This is also the reason why any new concept that is promulgated can be tested and confirmed, and by extension all fallacies are indeed very short-lived in the world of cardiac EP! For this reason, mechanistic studies will always be a feature of the journal. The permanent vector of all biomedical science is directed toward clinical care and therefore basic, translational, clinical, and population sciences are of interest for our readership and our team aims to make this content accessible and meaningful. The basic science on which the field of cardiac EP is founded is fascinating, revealing, and deserving of emphasis, as all current treatments can be traced to fundamental discoveries. Cardiac impulse formation is a story that started 3.4 billion years ago, when ionic fluxes needed membrane proteins and subsequently ion channels evolved to support life in a young earth. Ultimately nature refined this tool kit to ensure adaptation to life on land, evolving sinus rhythm in the hearts of our mammalian ancestors (about 160 million years ago). At a cellular and organ level, the muscle cells of the heart (only one-third of the cells in the heart are the myocytes) are activated in a synchronized manner to generate the biological marvel of excitation-contraction coupling. Indeed, the heart beats faithfully approximately 3 billion times in an 80-year life span. Myocytes are profoundly