CYTOTOXIC COMPOUNDS .4. SUBSTITUTED BENZYL HALIDES
CYTOTOXIC COMPOUNDS .4. SUBSTITUTED BENZYL HALIDES
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DOI：
10.1039/jr9630001947
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发表时间：
1963-01-01
期刊：
影响因子：
--
通讯作者：
OWEN, LN
中科院分区：
文献类型：
--
作者：
GRICE, R;OWEN, LN
这三种巯基苄醇是通过用氢化铝锂还原邻、间和对巯基苯甲酸甲酯而合成的，但每种醇与亚硫酰氯的反应仅得到无活性产物;因此，游离的巯基苄氯似乎与它们的酚类类似物一样难以接近。3-巯基苄醇也可通过酯化，然后用锂还原得到。哈特和赫希费尔德1a声称，这种单乙酸酯可由水杨酸一钾通过用1摩尔的水杨酸二钾处理或用1摩尔的水杨酸二钾处理来制备。在乙醚中的乙酸酐或与过量沸腾的乙酸酐反应。这些作者报告的分析（乙酰值）大概是指通过前一种方法获得的产物，因为在我们手中，后一种方法得到的是二乙酸酯。
The three mercaptobenzyl alcohols were synthesised by reduction of methyl o-, m-, and P-mercaptobenzoate with lithium aluminium hydride, but reaction of each alcohol with thionyl chloride gave only resinous products; it therefore appears that the free mercaptobenzyl chlorides are as inaccessible as their phenolic analogues. 3-Mercaptobenzyl alcohol was also obtained by esterification, followed by reduction with lithium* It is claimed by Hart and Hirschfelder la that this monoacetate can be prepared from monopotassium saligenate either by treatment with one mol. of acetic anhydride in ether or by reaction with an excess of boiling acetic anhydride. The analysis (acetyl value) reported by these authors presumably refers to the product obtained by the former method, since in our hands the latter procedure gave, as would be expected, the diacetate.