TorsinA regulates the LINC to moving nuclei.
TorsinA regulates the LINC to moving nuclei.
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DOI：
10.1083/jcb.201701054
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发表时间：
2017-03-06
期刊：
影响因子：
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通讯作者：
Rose LS
中科院分区：
文献类型：
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作者：
Starr DA;Rose LS
Starr和Rose讨论了Saunders等人的工作，证明torsinA和LAP 1在成纤维细胞极化过程中调节核运动。LINC复合物在核迁移过程中如何被调节以将核连接到细胞骨架尚不清楚。Saunders等人（2017. J. Cell Biol. https：//doi.org/10.1083/jcb.201507113）表明，AAA+ ATP酶torsinA及其伴侣LAP 1通过介导LINC复合物的动力学，是成纤维细胞极化期间核迁移所需的。
Starr and Rose discuss work by Saunders et al. demonstrating that torsinA and LAP1 regulate nuclear movement during fibroblast polarization. How LINC complexes are regulated to connect nuclei to the cytoskeleton during nuclear migration is unknown. Saunders et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201507113) show that the AAA+ ATPase torsinA and its partner LAP1 are required for nuclear migration during fibroblast polarization by mediating the dynamics of LINC complexes.