Histone methyltransferase Nsd2 is required for follicular helper T cell differentiation
Histone methyltransferase Nsd2 is required for follicular helper T cell differentiation
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滤泡辅助 T 细胞分化需要组蛋白甲基转移酶 Nsd2
DOI：
10.1084/jem.20190832
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发表时间：
2020-01-01
影响因子：
15.3
通讯作者：
Wang, Xiaoming
中科院分区：
文献类型：
--
作者：
Long, Xuehui;Zhang, Le;Wang, Xiaoming
在滤泡辅助性T细胞分化过程中Bcl 6表达的调节仍不完全清楚。在此，Long等人表明T细胞活化以CD28和ICOS依赖性方式诱导H3K36me2甲基转移酶Nsd2，以促进Bcl 6表达和Tfh分化。
Regulation of Bcl6 expression during follicular helper T cell differentiation remains incompletely understood. Here, Long et al. show that T cell activation induces H3K36me2 methyltransferase Nsd2, in a CD28- and ICOS-dependent manner, to promote Bcl6 expression and Tfh differentiation.