Genetic linkage studies in Alzheimer's disease
Genetic linkage studies in Alzheimer's disease
复制标题
阿尔茨海默病的遗传连锁研究
DOI：
10.1212/wnl.36.4.581
复制
发表时间：
1986
期刊：
影响因子：
9.9
通讯作者：
T. Weinberg
中科院分区：
文献类型：
--
作者：
M. Spence;A. Heyman;M. Marazita;R. Sparkes;T. Weinberg
我们研究了 18 个患有阿尔茨海默病的家庭，假设该疾病是由具有常染色体显性遗传形式的单个基因引起的。没有证据表明阿尔茨海默病与所分析的 27 个表型基因标记中的任何一个存在关联，但排除了 Rh 和 MNS 血型基因座的密切关联。
We studied 18 families with Alzheimer's disease in family members, under the assumption that the disease is due to a single gene with an autosomal dominant form of inheritance. There was no evidence of linkage of Alzheimer's disease with any of 27 phenotypic gene markers analyzed, but close linkage for the Rh and MNS blood group loci was excluded.